Molecular modeling of conformational dynamics and its role in enzyme evolution.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2018.08.004
Abstract: With increasing computational power, biomolecular simulations have become an invaluable tool for understanding enzyme mechanisms and the origins of enzyme catalysis. More recently, computational studies have started to focus on understanding how enzyme activity itself… read more here.
Keywords: molecular modeling; conformational dynamics; modeling conformational; role ... See more keywords
Enzyme evolution and the temperature dependence of enzyme catalysis.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2020.06.001
Abstract: Experiments and biomolecular simulations are revealing new and unexpected details of how enzymes are adapted to specific temperatures. These findings are elucidating enzyme evolutionary trajectories and offer great promise for design and engineering of natural… read more here.
Keywords: temperature; temperature dependence; enzyme evolution; dependence enzyme ... See more keywords
Integrating Enzyme Evolution and Metabolic Engineering to Improve the Productivity of Γ-Aminobutyric Acid by Whole-Cell Biosynthesis in Escherichia Coli.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c07613
Abstract: γ-Aminobutyric acid (GABA) is used widely in various fields, such as agriculture, food, pharmaceuticals, and biobased chemicals. Based on glutamate decarboxylase (GadBM4) derived from our previous work, three mutants, GadM4-2, GadM4-8, and GadM4-31, were obtained… read more here.
Keywords: enzyme evolution; aminobutyric acid; whole cell; integrating enzyme ... See more keywords