LAUSR

Enzyme function and its evolution.

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1 Published in 2017 at "Current opinion in structural biology"

DOI: 10.1016/j.sbi.2017.10.004

Abstract: With rapid increases over recent years in the determination of protein sequence and structure, alongside knowledge of thousands of enzyme functions and hundreds of chemical mechanisms, it is now possible to combine breadth and depth… read more here.

Keywords: function evolution; evolution; biology; function ... See more keywords

Prediction of Enzyme Function Based on a Structure Relation Network

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1 Published in 2020 at "IEEE Access"

DOI: 10.1109/access.2020.3010028

Abstract: Traditional biological experimental methods for enzyme function prediction have not been able to meet the increasing number of newly discovered enzymes measured by X-ray crystallography or magnetic resonance. A good computational model and protein feature… read more here.

Keywords: structure relation; structure; enzyme function; relation network ... See more keywords

Enzyme function prediction using contrastive learning

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2 Published in 2023 at "Science"

DOI: 10.1126/science.adf2465

Abstract: Enzyme function annotation is a fundamental challenge, and numerous computational tools have been developed. However, most of these tools cannot accurately predict functional annotations, such as enzyme commission (EC) number, for less-studied proteins or those… read more here.

Keywords: enzyme function; learning; annotation; contrastive learning ... See more keywords

Modulating Enzyme Function via Dynamic Allostery within Biliverdin Reductase B

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1 Published in 2021 at "Frontiers in Molecular Biosciences"

DOI: 10.3389/fmolb.2021.691208

Abstract: The biliverdin reductase B (BLVRB) class of enzymes catalyze the NADPH-dependent reduction of multiple flavin substrates and are emerging as critical players in cellular redox regulation. However, the role of dynamics and allostery have not… read more here.

Keywords: site; modulating enzyme; enzyme function; biliverdin reductase ... See more keywords

Parameter Reliability and Understanding Enzyme Function

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1 Published in 2022 at "Molecules"

DOI: 10.3390/molecules27010263

Abstract: Knowledge of the Michaelis–Menten parameters and their meaning in different circumstances is an essential prerequisite to understanding enzyme function and behaviour. The published literature contains an abundance of values reported for many enzymes. The problem… read more here.

Keywords: enzyme function; understanding enzyme; reliability understanding; parameter reliability ... See more keywords