Biologically active phthalocyanine metal complexes: Preparation, evaluation of α‐glycosidase and anticholinesterase enzyme inhibition activities, and molecular docking studies
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22765
Abstract: In this study, preparation, as well as investigation of α‐glycosidase and cholinesterase (ChE) enzyme inhibition activities of furan‐2‐ylmethoxy‐substituted compounds 1–7, are reported. Peripherally, tetra‐substituted copper and manganese phthalocyanines (5 and 6) were synthesized for the… read more here.
Keywords: glycosidase; enzyme inhibition; inhibition activities; metal complexes ... See more keywords
Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions.
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DOI: 10.1007/978-1-0716-1554-6_3
Abstract: This chapter describes the types of irreversible inhibition of drug-metabolizing enzymes and the methods commonly employed to quantify the irreversible inhibition and subsequently predict the extent and time course of clinically important drug-drug interactions. read more here.
Keywords: drug interactions; enzyme inhibition; inhibition; irreversible enzyme ... See more keywords
Evaluation of herb-drug interaction of a polyherbal Ayurvedic formulation through high throughput cytochrome P450 enzyme inhibition assay.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2016.07.061
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Arishtas are Ayurvedic formulation made with decoction of herbs. Arjunarishta formulation is being used in Ayurveda for cardio-protective activity. Ashwagandharishta formulation possesses antioxidant, anti-atherosclerotic and anti-stress properties. Ridayarishta, a novel empirical formulation was… read more here.
Keywords: enzyme inhibition; inhibition; formulation; inhibition assay ... See more keywords
Synthesis, crystal structure and Hirschfeld surface analyses of an alkyl amine based salt, [C5H16N2][ZnCl4] and its enzyme inhibition activity
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Saudi Chemical Society"
DOI: 10.1016/j.jscs.2016.12.002
Abstract: Abstract A novel ionic zinc salt based on alkyl amine is reported. The structure of the studied salt is established by crystal X-ray crystallography, FT-IR and NMR spectroscopy. Furthermore, Hirschfeld surface analyses of the studied… read more here.
Keywords: surface analyses; inhibition activity; enzyme inhibition; salt ... See more keywords
Metal based triazole compounds: Their synthesis, computational, antioxidant, enzyme inhibition and antimicrobial properties
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2018.05.036
Abstract: Abstract The present research work was aimed to synthesize biologically active Schiff base compound, 2-{(E)-[(3-{[(Z)-(2-hydroxyphenyl)methylidene]amino}-1H-1,2,4-triazol-5-yl)imino]methyl}phenol (L) by condensation reaction of 2-hydroxybenzaldehyde with 3,5-diamino-1,2,4-triazole. In order to evaluate the effect of metal ions on the biological… read more here.
Keywords: metal ions; antioxidant enzyme; metal based; enzyme inhibition ... See more keywords
Sulfonamide hybrid schiff bases of anthranilic acid: Synthesis, characterization and their biological potential
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.02.056
Abstract: Abstract In the present work, the novel Schiff bases (03–20) of 4-chloro-N-[2-(hydrazinocarbonyl) phenyl]benzenesulfonamide (02) were synthesized by reacting it with various aldehydes. 4-Chloro-N-[2-(hydrazinocarbonyl) phenyl]benzenesulfonamide (02) was synthesized by reacting methyl 2-{[(4-chlorophenyl)sulfonyl]amino}benzoate (01) with hydrazine. All… read more here.
Keywords: synthesized compounds; sulfonamide hybrid; inhibition; schiff bases ... See more keywords
Enzyme inhibition and antioxidant potential of new synthesized sulfonamides; synthesis, single crystal and molecular docking
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.130608
Abstract: Abstract This study describes the synthesis of four (1-4) new phenylalanine based sulfonamides from benzene sulfonyl chlorides. The progress of the reaction was monitored on TLC and after completion; the products were subjected to various… read more here.
Keywords: synthesis; single crystal; inhibition antioxidant; inhibition ... See more keywords
Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure–Activity Relationship, and X-ray Structural Studies
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c01214
Abstract: Here, we report the synthesis, structure–activity relationship studies, enzyme inhibition, antiviral activity, and X-ray crystallographic studies of 5-chloropyridinyl indole carboxylate derivatives as a potent class of SARS-CoV-2 chymotrypsin-like protease inhibitors. Compound 1 exhibited a SARS-CoV-2… read more here.
Keywords: enzyme inhibition; cov 3clpro; activity relationship; structure activity ... See more keywords
Synthesis, Characterization, and Enzyme Inhibition Properties of 1,2,4-Triazole Bearing Azinane Analogues
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DOI: 10.1021/acsomega.2c03779
Abstract: Considering the importance of acetylcholine esterase (AChE, BchE) and α-glucosidase in the treatment of Alzheimer’s disease and diabetes mellitus, the synthesis of novel azinane triazole-based derivatives as effective acetylcholinesterase (AchE), α-glucosidase, urease, lipoxygenase (LOX), and… read more here.
Keywords: inhibition; enzyme inhibition; azinane; glucosidase ... See more keywords
A novel method to engineer proteases for selective enzyme inhibition.
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DOI: 10.1039/c9cc08085f
Abstract: In this work, we have proposed a new strategy to expand the function of a protein. By taking a protease as an example, it can be engineered to make up the shortcoming of natural proteases,… read more here.
Keywords: proteases selective; selective enzyme; novel method; enzyme inhibition ... See more keywords
The use of dimethylsulfoxide as a solvent in enzyme inhibition studies: the case of aldose reductase
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2017.1363744
Abstract: Abstract Aldose reductase (AR) is an enzyme devoted to cell detoxification and at the same time is strongly involved in the aetiology of secondary diabetic complications and the amplification of inflammatory phenomena. AR is subjected… read more here.
Keywords: aldose reductase; inhibition studies; inhibition; enzyme inhibition ... See more keywords