Effect of Pevonedistat, an Investigational NEDD8‐Activating Enzyme Inhibitor, on the QTc Interval in Patients With Advanced Solid Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1194
Abstract: The purpose of this study was to assess the effect of pevonedistat, a neural precursor cell expressed, developmentally down‐regulated protein 8 (NEDD8)‐activating enzyme inhibitor, on the heart rate‐corrected QT (QTc) interval in cancer patients. Patients… read more here.
Keywords: nedd8 activating; activating enzyme; effect pevonedistat; qtc ... See more keywords
Affimer-enzyme-inhibitor switch sensor for rapid wash-free assays of multimeric proteins.
Sign Up to like & getrecommendations! Published in 2019 at "ACS sensors"
DOI: 10.1021/acssensors.9b01574
Abstract: Robust technology is required to underpin rapid point-of-care and in-field diagnostics, to improve timely decision making across broad sectors. An attractive strategy combines target recognition and signal generating elements into an "active" enzyme-switch that directly… read more here.
Keywords: inhibitor; enzyme inhibitor; inhibitor switch; switch sensor ... See more keywords
Integrated Treatment of Prostaglandin E1 and Angiotensin-Converting Enzyme Inhibitor in Diabetic Kidney Disease Rats: Possible Role of Antiapoptosis in Renal Tubular Epithelial Cells.
Sign Up to like & getrecommendations! Published in 2017 at "DNA and Cell Biology"
DOI: 10.1089/dna.2017.3690
Abstract: To investigate the therapeutic mechanisms underlying prostaglandin E1 (PGE1) and angiotensin-converting enzyme inhibitor (ACEI) on reducing urinary protein in diabetic kidney disease (DKD). DKD rat... read more here.
Keywords: prostaglandin; enzyme inhibitor; converting enzyme; angiotensin converting ... See more keywords
The Nedd8‐activating enzyme inhibitor MLN4924 (TAK‐924/Pevonedistat) induces apoptosis via c‐Myc‐Noxa axis in head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Cell Proliferation"
DOI: 10.1111/cpr.12536
Abstract: The present study aimed to reveal expression status of the neddylation enzymes in HNSCC and to elucidate the anticancer efficacy and the underlying mechanisms of inhibiting neddylation pathway. read more here.
Keywords: inhibitor mln4924; enzyme inhibitor; tak 924; nedd8 activating ... See more keywords
Abstract 6128: Deubiquitinating enzyme Inhibitor PR-619 inducesendoplasmic reticulum stress-related apoptosisin human chondrosarcoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6128
Abstract: It is reported that PR-619 is a deubiquitination enzyme inhibitor that can exert anti-tumor effects on a variety of malignancies. We conducted this study to explore the antitumor effects of PR-619 on chondrosarcoma in vitro… read more here.
Keywords: stress; human chondrosarcoma; chondrosarcoma; reticulum ... See more keywords
Rebuttal to Response to the Article “Enzyme–Inhibitor Interactions and a Simple, Rapid Method for Determining Inhibition Modality”
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DOI: 10.1177/2472555219875106
Abstract: The commentary by Dr. Walsh offers a depth of mathematical precision that is to be applauded. We congratulate him on this alternative mathematical treatment of enzyme– inhibitor interactions. At the same time, there is value… read more here.
Keywords: inhibitor; inhibition; enzyme inhibitor; inhibitor interactions ... See more keywords
Application of LpxC enzyme inhibitor to inhibit some fast-growing bacteria in human gut bacterial culturomics
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DOI: 10.1186/s12866-019-1681-6
Abstract: BackgroundCulturomics can ascertain traces of microorganisms to be cultivated using different strategies and identified by matrix-assisted laser desorption/ionization–time-of-flight mass spectrometry or 16S rDNA sequencing. However, to cater to all requirements of microorganisms and isolate as… read more here.
Keywords: human gut; lpxc enzyme; enzyme inhibitor; fast growing ... See more keywords
Angiotensin-Converting Enzyme Inhibitor– Associated Angioedema: From Bed to Bench
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DOI: 10.18176/jiaci.0458
Abstract: BACKGROUND AND OBJECTIVE Angiotensin-converting enzyme inhibitor-associated angioedema (ACEI-AAE) affects 0.1%-0.7% of patients treated with ACEIs. While previous research suggests that angioedema attacks result from increased vascular permeability, the pathogenesis is not completely understood. Objective: This… read more here.
Keywords: inhibitor associated; enzyme inhibitor; converting enzyme; angiotensin converting ... See more keywords
Efficacy of Zofenopril Alone or in Combination with Hydrochlorothiazide in Patients with Kidney Dysfunction.
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DOI: 10.2174/1574884713666181025145404
Abstract: Hypertension and kidney disease often coexist, further increasing the risk of future cardiovascular events. Treatment of hypertensive adults with an angiotensin converting enzyme inhibitor in case of concomitant kidney disease may slow disease progression. The… read more here.
Keywords: combination; zofenopril; enzyme inhibitor; converting enzyme ... See more keywords
The mechanism of oxidative stress in keloid fibroblasts and the experimental study of early application of angiotensin-converting enzyme inhibitor.
Sign Up to like & getrecommendations! Published in 2023 at "Indian journal of dermatology, venereology and leprology"
DOI: 10.25259/ijdvl_323_2022
Abstract: Objective To investigate the protective effects of an angiotensin-converting enzyme inhibitor after inducing oxidative stress on keloid fibroblasts. Methods Primary keloid fibroblasts were isolated and cultured by enzyme digestion combined with the tissue adhesion method… read more here.
Keywords: converting enzyme; inhibitor; oxidase; keloid fibroblasts ... See more keywords