LAUSR

Enzyme-instructed self-assembly enabled fluorescence light-up for alkaline phosphatase detection.

Sign Up to like & get
recommendations!
0 Published in 2021 at "Talanta"

DOI: 10.1016/j.talanta.2021.123078

Abstract: Alkaline phosphatase (ALP) exists in both normal and pathological tissues. Spatiotemporal variations in ALP levels can reveal its potential physiological functions and changes that occur during pathological conditions. However, it is still challenging to exploit… read more here.

Keywords: instructed self; self assembly; fluorescence; enzyme instructed ... See more keywords

Enzyme-Instructed Self-Assembly for Subcellular Targeting

Sign Up to like & get
recommendations!
0 Published in 2020 at "ACS Omega"

DOI: 10.1021/acsomega.0c02019

Abstract: Subcellular compartmentalization is a key feature of eukaryotic cells. Selectively targeting subcellular compartments, though holding many exciting opportunities for biomedicine, remains rather underdeveloped. Self-assembly provides a new way for subcellular targeting. In this mini-review, we… read more here.

Keywords: subcellular targeting; instructed self; self assembly; enzyme instructed ... See more keywords

Self-Assembling Ability Determines the Activity of Enzyme-Instructed Self-Assembly for Inhibiting Cancer Cells

Sign Up to like & get
recommendations!
0 Published in 2017 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.7b07147

Abstract: Enzyme-instructed self-assembly (EISA) represents a dynamic continuum of supramolecular nanostructures that selectively inhibits cancer cells via simultaneously targeting multiple hallmark capabilities of cancer, but how to design the small molecules for EISA from the vast… read more here.

Keywords: self assembling; assembling ability; enzyme instructed; cancer cells ... See more keywords

Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications

Sign Up to like & get
recommendations!
1 Published in 2022 at "Molecules"

DOI: 10.3390/molecules27196557

Abstract: Despite the remarkable significance and encouraging breakthroughs of intracellular enzyme-instructed self-assembly of peptides (IEISAP) in disease diagnosis and treatment, a comprehensive review that focuses on this topic is still desirable. In this article, we carefully… read more here.

Keywords: assembly peptides; self assembly; intracellular enzyme; enzyme instructed ... See more keywords

Enzyme-instructed morphological transition of the supramolecular assemblies of branched peptides

Sign Up to like & get
recommendations!
0 Published in 2020 at "Beilstein Journal of Organic Chemistry"

DOI: 10.3762/bjoc.16.221

Abstract: Here, we report the use of an enzymatic reaction to cleave the branch off branched peptides for inducing the morphological transition of the assemblies of the peptides. The attachment of DEDDDLLI sequences to the ε-amine… read more here.

Keywords: instructed morphological; supramolecular assemblies; branched peptides; enzyme instructed ... See more keywords