Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-20-0176
Abstract: Malic enzyme 1 (ME1) is a cytosolic protein that catalyzes the conversion of malate to pyruvate while concomitantly generating NADPH from NADP. Early studies identified ME1 as a mediator of intermediary metabolism primarily through its… read more here.
Keywords: enzyme me1; malic enzyme; intermediary metabolism; me1 ... See more keywords
Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076613
Abstract: Malic Enzyme 1 (ME1) supports lipogenesis, cholesterol synthesis, and cellular redox potential by catalyzing the decarboxylation of L-malate to pyruvate, and the concomitant reduction of NADP to NADPH. We examined the contribution of ME1 to… read more here.
Keywords: female mice; malic enzyme; insulin leptin; mice ... See more keywords