Enzyme‐mediated synthesis of Molnupiravir: paving the way for the application of biocatalysis in pharmaceutical industry
Sign Up to like & getrecommendations! Published in 2022 at "ChemCatChem"
DOI: 10.1002/cctc.202200140
Abstract: Molnupiravir (Lagevrio®) is an orally‐administered anti‐COVID‐19 agent. Due to the urgency to meet the worldwide demand and the growing environmental concern, there is a need for speed in the industrial implementation of novel and efficient… read more here.
Keywords: molnupiravir paving; mediated synthesis; synthesis; enzyme mediated ... See more keywords
Enzyme-mediated intratumoral self-assembly of nanotheranostics for enhanced imaging and tumor therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1786
Abstract: Enzyme-mediated intratumoral self-assembled (EMISA) nanotheranostics represent a new class of smart agents for combined imaging and therapy of cancer. Cancer cells overexpress various enzymes that are essential for high metabolism, fast proliferation, and tissue invasion… read more here.
Keywords: self assembly; therapy; enzyme mediated; intratumoral self ... See more keywords
Keratinolytic enzyme-mediated biodegradation of recalcitrant poultry feathers waste by newly isolated Bacillus sp. NKSP-7 under submerged fermentation
Sign Up to like & getrecommendations! Published in 2020 at "Folia Microbiologica"
DOI: 10.1007/s12223-020-00793-6
Abstract: Microbial and enzymatic degradation of keratin waste is more preferred over various conventional approaches which are costly and not environmentally suitable. Diverse niches are auspicious for the discovery of new microorganisms. To discover novel keratinolytic… read more here.
Keywords: mediated biodegradation; bacillus nksp; poultry; enzyme mediated ... See more keywords
An enzyme-mediated protein-fragment complementation assay for substrate screening of sortase A.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.016
Abstract: Enzyme-mediated protein conjugation has gained great attention recently due to the remarkable site-selectivity and mild reaction condition affected by the nature of enzyme. Among all sorts of enzymes reported, sortase A from Staphylococcus aureus (SaSrtA)… read more here.
Keywords: fragment complementation; protein fragment; enzyme; enzyme mediated ... See more keywords
The use of steam pretreatment to enhance pellet durability and the enzyme-mediated hydrolysis of pellets to fermentable sugars.
Sign Up to like & getrecommendations! Published in 2022 at "Bioresource technology"
DOI: 10.1016/j.biortech.2022.126731
Abstract: Although densified wood pellets are an attractive biomass feedstock for bioenergy and biofuels production, partly due to their ease of transport, their friability and hygroscopic nature (attraction of moisture) have proven problematic in terms of… read more here.
Keywords: mediated hydrolysis; biomass; pellet durability; steam pretreatment ... See more keywords
Enzyme-mediated tagging of RNA.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2017.03.013
Abstract: RNA molecules can play diverse roles in the cell owing to their secondary structure dynamics and various binding modes. Studying localization and dynamics of RNA in vitro or in cells requires tagging with suitable reporter… read more here.
Keywords: rna; chemistry; mediated tagging; tagging rna ... See more keywords
Enzyme-mediated tissue adhesive hydrogels for meniscus repair.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.12.053
Abstract: Meniscus tissues have limited regenerative capacity once damaged. The treatment options for the meniscus tissue regeneration have been limited to arthroscopic meniscectomy or surgical interventions. The injectable hydrogels based system would provide an alternative to… read more here.
Keywords: meniscus repair; tissue adhesive; adhesive hydrogels; tissue ... See more keywords
Cucurbit-Like Polymersomes with Aggregation-Induced Emission Properties Show Enzyme-Mediated Motility.
Sign Up to like & getrecommendations! Published in 2021 at "ACS nano"
DOI: 10.1021/acsnano.1c07343
Abstract: Polymersomes that incorporate aggregation-induced emission (AIE) moieties are attractive inherently fluorescent nanoparticles with biomedical application potential for cell/tissue imaging and tracking, as well as phototherapeutics. An intriguing feature that has not been explored yet is… read more here.
Keywords: cucurbit; cucurbit like; aggregation induced; enzyme mediated ... See more keywords
Unnatural cyclodextrins can be accessed from enzyme-mediated dynamic combinatorial libraries.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06452e
Abstract: Dynamic systems of cyclodextrins (CDs) enabled by a native cyclodextrin glucanotransferase (CGTase) can incorporate unnatural glucopyranose-derived building blocks, expanding the applicability of enzyme-mediated dynamic combinatorial chemistry by using synthetically modified substrates. Starting dynamic combinatorial libraries… read more here.
Keywords: unnatural cyclodextrins; dynamic combinatorial; combinatorial libraries; mediated dynamic ... See more keywords
An enzyme-mediated bioorthogonal labeling method for genome-wide mapping of 5-hydroxymethyluracil
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Science"
DOI: 10.1039/d1sc03812e
Abstract: DNA 5-hydroxymethyluracil (5hmU) is a thymine modification existing in the genomes of various organisms. The post-replicative formation of 5hmU occurs via hydroxylation of thymine by ten-eleven translocation (TET) dioxygenases in mammals and J-binding proteins (JBPs)… read more here.
Keywords: enzyme mediated; bioorthogonal labeling; labeling method; mediated bioorthogonal ... See more keywords
Enzyme-Mediated Lignocellulose Liquefaction Is Highly Substrate-Specific and Influenced by the Substrate Concentration or Rheological Regime
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.00917
Abstract: The high viscosities/yield stresses of lignocellulose slurries makes their industrial processing a significant challenge. However, little is known regarding the degree to which liquefaction and its enzymatic requirements are specific to a substrate’s physicochemical and… read more here.
Keywords: lignocellulose liquefaction; mediated lignocellulose; liquefaction; enzyme mediated ... See more keywords