Dual Intratumoral Redox/Enzyme-Responsive NO-Releasing Nanomedicine for the Specific, High-Efficacy, and Low-Toxic Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced materials"
DOI: 10.1002/adma.201704490
Abstract: Chemotherapy suffers numbers of limitations including poor drug solubility, nonspecific biodistribution, and inevitable adverse effects on normal tissues. Tumor-targeted delivery and intratumoral stimuli-responsive release of drugs by nanomedicines are considered to be highly promising in… read more here.
Keywords: dual intratumoral; responsive releasing; redox enzyme; intratumoral redox ... See more keywords
An Enzyme‐Responsive Self‐Immolative Recognition Marker for Manipulating Cell–Cell Interactions (Adv. Sci. 36/2024)
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202470221
Abstract: Living Sells as Chemicals Cell‐cell interactions can be manipulated ‘on demand’ using self‐responsive chemical tools. In the article number 2402278, Sébastien Papot and his colleagues show that enzyme‐sensitive cell surface markers enable the formation and… read more here.
Keywords: cell cell; responsive self; self immolative; cell interactions ... See more keywords
Stimulus‐Responsive Amino Acids Behind In Situ Assembled Bioactive Peptide Materials
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200497
Abstract: In situ self‐assembly of peptides into well‐defined nanostructures represents one of versatile strategies for creation of bioactive materials within living cells with great potential in disease diagnosis and treatment. The intimate relationship between amino acid… read more here.
Keywords: amino acids; situ; stimulus responsive; responsive amino ... See more keywords
Enzyme-responsive polysaccharide supramolecular nanoassembly for enhanced DNA encapsulation and controlled release
Sign Up to like & getrecommendations! Published in 2021 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2021.01.032
Abstract: Abstract An enzyme-responsive polysaccharide supramolecular targeted nanoassembly was successfully constructed by the host-guest complexation of positively charged mono-(6-(tetraethylenepentamine)-6-deoxy)-β-cyclodextrin (TEPA-CD) with adamantane-grafted hyaluronic acid (HA-ADA). Possessing a series of positively charged polyamine chains, the obtained polysaccharide… read more here.
Keywords: enzyme responsive; polysaccharide supramolecular; responsive polysaccharide; release ... See more keywords
Endocytosis Pathway Self-Regulation for Precise Image-Guided Therapy through an Enzyme-Responsive Modular Peptide Probe.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c00776
Abstract: Before arriving at the intracellular destinations, probes might be trapped in the lysosomes, reducing the amount of cargos, which compromises the therapeutic outcomes. The current methods are based on the fact that probes enter the… read more here.
Keywords: responsive modular; enzyme responsive; endocytosis; image guided ... See more keywords
Phospholipidic Colchicinoids as Promising Prodrugs Incorporated into Enzyme-Responsive Liposomes: Chemical, Biophysical, and Enzymological Aspects.
Sign Up to like & getrecommendations! Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00051
Abstract: Enzyme-responsive liposomes release their cargo in response to pathologically increased levels of enzymes at the target site. We report herein an assembly of phospholipase A2-responsive liposomes based on colchicinoid lipid prodrugs incorporated into lipid bilayer… read more here.
Keywords: lipid prodrugs; responsive liposomes; enzyme responsive; colchicinoids promising ... See more keywords
Programmable Fabrics of Enzyme-Responsive Amphiphiles: A Multiscale Platform for Hierarchical Mesophase Transformations
Sign Up to like & getrecommendations! Published in 2025 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.4c01649
Abstract: Systems capable of undergoing a controlled cascade of mesophase transitions across hierarchical scales represent a novel class of dynamic materials. Here, we describe an electrospun polymeric fabric composed of enzyme-responsive di- and triblock copolymers that… read more here.
Keywords: responsive amphiphiles; amphiphiles multiscale; mesophase; programmable fabrics ... See more keywords
Modular Synthetic Approach for Adjusting the Disassembly Rates of Enzyme-Responsive Polymeric Micelles.
Sign Up to like & getrecommendations! Published in 2017 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.6b01906
Abstract: Self-assembled nanostructures and their stimuli-responsive degradation have been recently explored to meet the increasing need for advanced biocompatible and biodegradable materials for various biomedical applications. Incorporation of enzymes as triggers that can stimulate the degradation… read more here.
Keywords: modular synthetic; enzyme responsive; approach adjusting; end groups ... See more keywords
A pH-/Enzyme-Responsive Nanoparticle Selectively Targets Endosomal Toll-like Receptors to Potentiate Robust Cancer Vaccination.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c00185
Abstract: Toll-like receptor (TLR) agonists are potent immune-stimulators that hold great potential in vaccine adjuvants as well as cancer immunotherapy. However, TLR agonists in free form are prone to be eliminated quickly by the circulatory system… read more here.
Keywords: responsive nanoparticle; enzyme responsive; toll like; cancer ... See more keywords
Intracellular Enzyme-Responsive Profluorophore and Prodrug Nanoparticles for Tumor-Specific Imaging and Precise Chemotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c19058
Abstract: Responsive drug delivery systems possess great potential in disease diagnosis and treatment. Herein, we develop an activatable prodrug and fluorescence imaging material by engineering the endogenous NAD(P)H:quinone oxidoreductase-1 (NQO1) responsive linker. The as-prepared nanomaterials possess… read more here.
Keywords: prodrug; chemotherapy; enzyme responsive; tumor specific ... See more keywords
Beta-Sitosterol-Conjugated Sinapic Acid-Engineered Nanoliposome: Biomucoadhesive and Enzyme-Responsive Targeted Oral Therapy in Ulcerative Colitis.
Sign Up to like & getrecommendations! Published in 2025 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.5c02190
Abstract: Developing oral drug delivery systems is promising for ulcerative colitis (UC). However, the key challenges, including formulation degradation under harsh gastric conditions, poor targeting efficiency, and limited colonic residence, lead to poor therapeutic efficacy that… read more here.
Keywords: enzyme responsive; ulcerative colitis; beta sitosterol; sinapic acid ... See more keywords