Mechanism of Radical Initiation in the Radical SAM Enzyme Superfamily.
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DOI: 10.1146/annurev-biochem-052621-090638
Abstract: Radical S-adenosylmethionine (SAM) enzymes use a site-differentiated [4Fe-4S] cluster and SAM to initiate radical reactions through liberation of the 5'-deoxyadenosyl (5'-dAdo•) radical. They form the largest enzyme superfamily, with more than 700,000 unique sequences currently, and… read more here.
Keywords: radical sam; sam; enzyme superfamily; mechanism radical ... See more keywords