Malic enzyme 2 as a therapeutic target for cancer: comments on ‘Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate’
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjac024
Abstract: In mammalian cells, there are three isoforms of malic enzymes (MEs): a cytosolic nicotinamide adenine dinucleotide phosphate + (NADP + )-dependent isoform (ME1), a mitochondrial NAD(P) + -dependent isoform (ME2), and a mitochondrial NADP +… read more here.
Keywords: therapeutic target; malic enzyme; dependent isoform; enzyme therapeutic ... See more keywords