Engineering Bifunctional Enzymes Capable of Adenylating and Selectively Methylating the Side Chain or Core of Amino Acids.
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DOI: 10.1021/acssynbio.7b00426
Abstract: Nonribosomal peptides (NRPs) are known sources of therapeutics. Some nonribosomal peptide synthetase assembly lines contain unique functional interrupted adenylation (A) domains, where nature has combined two different functional domains into one bifunctional enzyme. Most often… read more here.
Keywords: bifunctional enzymes; engineering bifunctional; enzymes capable; capable adenylating ... See more keywords