Current strategies for the development of fluorescence-based molecular probes for visualizing the enzymes and proteins associated with Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Coordination Chemistry Reviews"
DOI: 10.1016/j.ccr.2020.213553
Abstract: Abstract One of the most prevalent forms of dementia is Alzheimer's disease (AD) which causes severe memory impairment within humans. As such, research into the early diagnosis of AD is essential to help treatment, which… read more here.
Keywords: current strategies; fluorescence; alzheimer disease; enzymes proteins ... See more keywords
Redirecting RiPP Biosynthetic Enzymes to Proteins and Backbone-Modified Substrates
Sign Up to like & getrecommendations! Published in 2022 at "ACS Central Science"
DOI: 10.1021/acscentsci.1c01577
Abstract: Ribosomally synthesized and post-translationally modified peptides (RiPPs) are peptide-derived natural products that include the FDA-approved analgesic ziconotide1,2 as well as compounds with potent antibiotic, antiviral, and anticancer properties.3 RiPP enzymes known as cyclodehydratases and dehydrogenases… read more here.
Keywords: backbone modified; biosynthetic enzymes; enzymes proteins; redirecting ripp ... See more keywords
How Enzymes, Proteins, and Antibodies Recognize Extended DNAs; General Regularities
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DOI: 10.3390/ijms22031369
Abstract: X-ray analysis cannot provide quantitative estimates of the relative contribution of non-specific, specific, strong, and weak contacts of extended DNA molecules to their total affinity for enzymes and proteins. The interaction of different enzymes and… read more here.
Keywords: general regularities; enzymes proteins; dna; proteins antibodies ... See more keywords