Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate
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DOI: 10.1080/19490976.2022.2107289
Abstract: ABSTRACT Mycophenolate mofetil (MMF) is an important immunosuppressant prodrug prescribed to prevent organ transplant rejection and to treat autoimmune diseases. MMF usage, however, is limited by severe gastrointestinal toxicity that is observed in approximately 45%… read more here.
Keywords: mycophenolate; enzymes reactivate; gus; activity based ... See more keywords