Identification of enzymes responsible for nitrazepam metabolism and toxicity in human
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2017.06.114
Abstract: &NA; Nitrazepam (NZP) is a hypnotic agent that rarely causes liver injuries in humans and teratogenicity in rodents. In humans, NZP is primarily metabolized to 7‐aminonitrazepam (ANZP) by reduction and subsequently to 7‐acetylamino nitrazepam (AANZP)… read more here.
Keywords: metabolism; enzymes responsible; responsible nitrazepam; nzp reductase ... See more keywords
Identification of key enzymes responsible for protolimonoid biosynthesis in plants: Opening the door to azadirachtin production
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1906083116
Abstract: Significance Limonoids are natural products made by members of the Meliaceae and Rutaceae families. Some limonoids (e.g., azadirachtin) are toxic to insects yet harmless to mammals. The use of limonoids in crop protection and other… read more here.
Keywords: biosynthesis; production; enzymes responsible; azadirachtin ... See more keywords
Diurnal Changes in Capecitabine Clock-Controlled Metabolism Enzymes Are Responsible for Its Pharmacokinetics in Male Mice
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Biological Rhythms"
DOI: 10.1177/07487304221148779
Abstract: The circadian timing system controls absorption, distribution, metabolism, and elimination processes of drug pharmacokinetics over a 24-h period. Exposure of target tissues to the active form of the drug and cytotoxicity display variations depending on… read more here.
Keywords: diurnal changes; metabolism; capecitabine; phase ... See more keywords