CncC/Maf-mediated xenobiotic response pathway in insects.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.21674
Abstract: Insects have evolved resistance to almost all insecticides developed for their control. Multiple mechanisms of resistance, including enhanced metabolism and excretion of insecticides, target-site insensitivity, reduced penetration of insecticides, and avoidance behavior, have been reported.… read more here.
Keywords: insects; cncc maf; maf mediated; pathway ... See more keywords
Systems pharmacology modeling of drug‐induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.619
Abstract: Elevations in serum bilirubin during drug treatment may indicate global liver dysfunction and a high risk of liver failure. However, drugs also can increase serum bilirubin in the absence of hepatic injury by inhibiting specific… read more here.
Keywords: inhibition; hyperbilirubinemia; drug; pharmacology ... See more keywords
Cross-species analysis of hepatic cytochrome P450 and transport protein expression
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Toxicology"
DOI: 10.1007/s00204-020-02939-4
Abstract: Most drugs and xenobiotics are metabolized in the liver. Amongst others, different cytochrome P450 (CYP) enzymes catalyze the metabolic conversion of foreign compounds, and various transport proteins are engaged in the excretion of metabolites from… read more here.
Keywords: cross species; transport; p450; cytochrome p450 ... See more keywords
Effect of cholecystectomy on bile acids as well as relevant enzymes and transporters in mice: Implication for pharmacokinetic changes of rifampicin
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2016.09.006
Abstract: Background and purpose: Long‐term medical consequences of cholecystectomy are believed to be uncommon. It has been reported that bile acids (BAs) changed after cholecystectomy. As important signaling molecules, the alternations of BAs might favour the… read more here.
Keywords: bile acids; relevant enzymes; effect; enzymes transporters ... See more keywords
Evaluation of potential herb-drug interactions based on the effect of Suxiao Jiuxin Pill on CYP450 enzymes and transporters.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114408
Abstract: ETHNOPHARMACOLOGY RELEVANCE Suxiao jiuxin pill (SJP) is a Chinese medical drug with anti-inflammatory, anti-apoptotic, and vasodilatory function. It is widely used in combination with other drugs for the treatment of coronary heart disease (CHD) and… read more here.
Keywords: effect; drug; sjp; enzymes transporters ... See more keywords
Alterations of drug-metabolizing enzymes and transporters under diabetic conditions: what is the potential clinical significance?
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism Reviews"
DOI: 10.1080/03602532.2018.1497645
Abstract: Abstract There will be 642 million people worldwide by 2040 suffering from diabetes mellitus. Long-term multidrug therapy aims to achieve normal glycemia and minimize complications, and avoid severe hypoglycemic events. The appreciation of the drug-metabolizing… read more here.
Keywords: drug metabolizing; drug; metabolizing enzymes; enzymes transporters ... See more keywords
Impact of Microbiome on Hepatic Metabolizing Enzymes and Transporters in Mice during Pregnancy
Sign Up to like & getrecommendations! Published in 2020 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.120.000039
Abstract: The microbiome and pregnancy are known to alter drug disposition, yet the interplay of the two physiologic factors on the expression and/or activity of drug metabolizing enzymes and transporters (DMETs) is unknown. This study investigated… read more here.
Keywords: pregnancy; expression activity; metabolizing enzymes; mice ... See more keywords
Label-Free but Still Constrained: Assessment of Global Proteomic Strategies for the Quantification of Hepatic Enzymes and Transporters
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.121.000780
Abstract: Building and refining pharmacology models require “system” data derived from tissues and in vitro systems analyzed by quantitative proteomics. Label-free global proteomics offers a wide scope of analysis, allowing simultaneous quantification of thousands of proteins… read more here.
Keywords: enzymes transporters; label free; free still; free proteomic ... See more keywords
Type 2 diabetes: an exploratory genetic association analysis of selected metabolizing enzymes and transporters and effects on cardiovascular and renal biomarkers
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Personalized Therapy"
DOI: 10.1515/dmpt-2021-0135
Abstract: Abstract Objectives This study sought to identify potential pharmacogenetic associations of selected enzymes and transporters with type 2 diabetes (T2D). In addition, pharmacogenomic profiles, concentrations of asymmetric dimethylarginine (ADMA) or kidney injury molecule-1 (KIM-1), and… read more here.
Keywords: enzymes transporters; diabetes exploratory; exploratory genetic; type diabetes ... See more keywords
Interplay between Epigenetics and Cellular Metabolism in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11101406
Abstract: Cellular metabolism alterations have been recognized as one of the most predominant hallmarks of colorectal cancers (CRCs). It is precisely regulated by many oncogenic signaling pathways in all kinds of regulatory levels, including transcriptional, post-transcriptional,… read more here.
Keywords: metabolism; cellular metabolism; interplay epigenetics; metabolic enzymes ... See more keywords