Sputum IL-25, IL-33 and TSLP, IL-23 and IL-36 in airway obstructive diseases. Reduced levels of IL-36 in eosinophilic phenotype.
Sign Up to like & getrecommendations! Published in 2021 at "Cytokine"
DOI: 10.1016/j.cyto.2021.155421
Abstract: INTRODUCTION Alarmins ((IL-25, IL-33 and thymic stromal lymphopoietin (TSLP)) are known to promote Th2 inflammation and could be associated with eosinophilic airway infiltration. They may also play a role in airway remodeling in chronic airway… read more here.
Keywords: eosinophilic airway; airway obstructive; inflammation; obstructive diseases ... See more keywords
Charcot-Leyden crystal protein/galectin-10 is a surrogate biomarker of eosinophilic airway inflammation in asthma.
Sign Up to like & getrecommendations! Published in 2019 at "Biomarkers in medicine"
DOI: 10.2217/bmm-2018-0280
Abstract: Aim: Eosinophilic asthma is associated with more exacerbations and differential responses to treatment. The aim of this study was to assess if CLC/Gal-10 and MBP-1 are surrogate biomarkers of eosinophilic inflammation in asthma. Methods & results:… read more here.
Keywords: gal mbp; inflammation asthma; eosinophilic airway; clc gal ... See more keywords
CCL4 Regulates Eosinophil Activation in Eosinophilic Airway Inflammation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232416149
Abstract: Eosinophilic chronic rhinosinusitis (ECRS) is a refractory airway disease accompanied by eosinophilic inflammation, the mechanisms of which are unknown. We recently found that CCL4/MIP-1β—a specific ligand for CCR5 receptors—was implicated in eosinophil recruitment into the… read more here.
Keywords: inflammation; ccl4; airway inflammation; eosinophil activation ... See more keywords
Eosinophilic Airway Diseases: From Pathophysiological Mechanisms to Clinical Practice
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087254
Abstract: Eosinophils play a key role in airway inflammation in many diseases, such as allergic and non-allergic asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive pulmonary disease. In these chronic disabling conditions, eosinophils contribute to… read more here.
Keywords: diseases pathophysiological; mechanisms clinical; pathophysiological mechanisms; airway diseases ... See more keywords