Interleukin‐33 increases type 2 innate lymphoid cell count and their activation in eosinophilic asthma
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and Translational Allergy"
DOI: 10.1002/clt2.12265
Abstract: Abstract Background Interleukin‐33 (IL‐33) exacerbates asthma probably through type 2 innate lymphoid cells (ILC2s). Nevertheless, the association between eosinophilic asthma (EA) and ILC2s remains obscure, and the mechanisms by which IL‐33 affects ILC2s are yet… read more here.
Keywords: interleukin; eosinophilic asthma; innate lymphoid; ilc2s ... See more keywords
Subcutaneous mepolizumab in children aged 6 to 11 years with severe eosinophilic asthma
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.24508
Abstract: There are no published reports for anti‐interleukin‐5 therapy in children read more here.
Keywords: children aged; severe eosinophilic; mepolizumab children; eosinophilic asthma ... See more keywords
Mepolizumab and Benralizumab in Severe Eosinophilic Asthma: Preliminary Results of a Proteomic Study
Sign Up to like & getrecommendations! Published in 2020 at "Lung"
DOI: 10.1007/s00408-020-00379-6
Abstract: Benralizumab and mepolizumab are new therapies for severe eosinophilic asthma. They are both humanized IgG antibodies, targeting the IL‐5 receptor and IL‐5, respectively, suppressing the corresponding pathways. No specific biomarkers have been proposed to evaluate… read more here.
Keywords: eosinophilic asthma; mepolizumab benralizumab; severe eosinophilic; proteomic study ... See more keywords
Eosinophilic asthma, according to a blood eosinophil criterion, is associated with disease severity and lack of control among underprivileged urban Brazilians.
Sign Up to like & getrecommendations! Published in 2018 at "Respiratory medicine"
DOI: 10.1016/j.rmed.2018.10.025
Abstract: BACKGROUND Asthma is a syndrome with multiple phenotypes. Peripheral blood eosinophil counts might be the ideal biomarker to identify subjects with eosinophilic asthma. It is available, inexpensive, and it is associated with eosinophilia in sputum.… read more here.
Keywords: blood eosinophil; control; eosinophilic asthma; severity ... See more keywords
Synergistic activation of pro-inflammatory type-2 CD8+ T lymphocytes by lipid mediators in severe eosinophilic asthma
Sign Up to like & getrecommendations! Published in 2018 at "Mucosal Immunology"
DOI: 10.1038/s41385-018-0049-9
Abstract: Human type-2 CD8+ T cells are a cell population with potentially important roles in allergic disease. We investigated this in the context of severe asthma with persistent airway eosinophilia—a phenotype associated with high exacerbation risk… read more here.
Keywords: eosinophilic asthma; pro inflammatory; severe eosinophilic; type cd8 ... See more keywords
The prevalence and disease burden of severe eosinophilic asthma in Japan
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Asthma"
DOI: 10.1080/02770903.2018.1534967
Abstract: Abstract Background: There are limited data on the prevalence and burden of severe eosinophilic asthma (SEA) both in Japan and globally. This study aimed to assess the prevalence and burden of SEA in Japan. Methods:… read more here.
Keywords: sea; prevalence; japan; eosinophilic asthma ... See more keywords
Effectiveness of mepolizumab in patients with severe eosinophilic asthma: results from real-world clinical practice in Finland
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Asthma"
DOI: 10.1080/02770903.2021.2020813
Abstract: Abstract Objectives Mepolizumab treatment provides clinical benefits for patients with severe eosinophilic asthma in randomized controlled trials. However, real-world data for patients in Finland are lacking. Methods This retrospective, non-interventional, chart review study included patients… read more here.
Keywords: eosinophilic asthma; asthma; patients severe; severe eosinophilic ... See more keywords
Cost-effectiveness of benralizumab versus mepolizumab and dupilumab in patients with severe uncontrolled eosinophilic asthma in Spain
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Asthma"
DOI: 10.1080/02770903.2022.2139718
Abstract: Abstract Objective To assess the cost-effectiveness of benralizumab (benra) vs. mepolizumab (mepo) and dupilumab (dupi) for the treatment of patients with severe uncontrolled asthma from the Spanish Health System perspective. Methods Exacerbations avoided, quality-adjusted life… read more here.
Keywords: effectiveness benralizumab; eosinophilic asthma; asthma; patients severe ... See more keywords
Biological therapies for eosinophilic asthma
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2018.1492540
Abstract: ABSTRACT Introduction: Severe uncontrolled asthma is by definition refractory to traditional therapies or can be controlled only with therapies that have intolerable side effects. Monoclonal antibodies that target interleukin (IL)-5/IL-5Rα, IgE, and IL-4Rα have shown… read more here.
Keywords: severe eosinophilic; therapies eosinophilic; eosinophilic asthma; clinical trials ... See more keywords
Asthma inflammatory phenotypes on four continents: most asthma is non-eosinophilic
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Epidemiology"
DOI: 10.1093/ije/dyac173
Abstract: Abstract Background Most studies assessing pathophysiological heterogeneity in asthma have been conducted in high-income countries (HICs), with little known about the prevalence and characteristics of different asthma inflammatory phenotypes in low-and middle-income countries (LMICs). This… read more here.
Keywords: eosinophilic asthma; inflammatory phenotypes; phenotypes four; asthma inflammatory ... See more keywords
Regulatory T cell monitoring in severe eosinophilic asthma patients treated with mepolizumab
Sign Up to like & getrecommendations! Published in 2021 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.13031
Abstract: Severe eosinophilic asthma (SEA) has been associated with T‐helper type 2 (Th2) inflammatory response. A good understanding of T cell functions in asthma is important for therapy, especially in the choice of biological treatments for… read more here.
Keywords: severe eosinophilic; eosinophilic asthma; asthma; treated mepolizumab ... See more keywords