The epidermal growth factor receptor inhibitor AG1478 inhibits eosinophilic inflammation in upper airways.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical immunology"
DOI: 10.1016/j.clim.2017.11.010
Abstract: Mucus hypersecretion and eosinophil infiltration are important characteristics of eosinophilic inflammation in upper airways, such as allergic rhinitis and chronic rhinosinusitis with nasal polyp. EGFR transactivation induces mucus and inflammatory cytokine secretion from airway epithelial… read more here.
Keywords: inhibitor ag1478; inflammation upper; upper airways; eosinophilic inflammation ... See more keywords
Impact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohort
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DOI: 10.1183/13993003.00853-2017
Abstract: Eosinophilic inflammation in chronic obstructive pulmonary disease (COPD) predicts response to treatment, especially corticosteroids. We studied the nature of eosinophilic inflammation in COPD prospectively to examine the stability of this phenotype and its dynamics across… read more here.
Keywords: eosinophilic inflammation; inflammation; blood; inflammation copd ... See more keywords
Stability of eosinophilic inflammation in COPD bronchial biopsies
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DOI: 10.1183/13993003.04167-2020
Abstract: We thank E.H. Walters and co-workers for their interest in our recently published research letter “Stability of eosinophilic inflammation in COPD bronchial biopsies” [1]. We would like to provide clarity on several points raised. Correspondence:… read more here.
Keywords: copd bronchial; eosinophilic inflammation; inflammation copd; bronchial biopsies ... See more keywords
Eosinophilic inflammation: An Appealing Target for Pharmacologic Treatments in Severe Asthma
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DOI: 10.3390/biomedicines10092181
Abstract: Severe asthma is characterized by different endotypes driven by complex pathologic mechanisms. In most patients with both allergic and non-allergic asthma, predominant eosinophilic airway inflammation is present. Given the central role of eosinophilic inflammation in… read more here.
Keywords: inflammation; inflammation appealing; target pharmacologic; eosinophilic inflammation ... See more keywords
The effect of systemic treatments on periostin expression reflects their interference with the eosinophilic inflammation in chronic rhinosinusitis with nasal polyps.
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DOI: 10.4193/rhin16.314
Abstract: BACKGROUND Periostin is a recently discovered biomarker for eosinophilic inflammation. Chronic rhinosinusitis with nasal polyps is a T-helper 2-skewed chronic inflammatory airway disease. Medical treatments aim to relieve symptoms and maintain clinical control by interfering… read more here.
Keywords: effect; periostin expression; periostin; eosinophilic inflammation ... See more keywords