Identification of de novo EP300 and PLAU variants in a patient with Rubinstein–Taybi syndrome-related arterial vasculopathy and skeletal anomaly
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-95133-0
Abstract: Rubinstein–Taybi syndrome (RSTS) is a human genetic disorder characterized by distinctive craniofacial features, broad thumbs and halluces, and intellectual disability. Mutations in the CREB binding protein (CREBBP) and E1A binding protein p300 (EP300) are the… read more here.
Keywords: ep300; plau; ep300 plau; rubinstein taybi ... See more keywords
KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abl4618
Abstract: EP300, a transcription coactivator important in proliferation and differentiation, is frequently mutated in diverse cancer types, including small cell lung cancer (SCLC). While these mutations are thought to result in loss of EP300 function, the… read more here.
Keywords: cell; ep300; domain; kix domain ... See more keywords
Abstract 978: In vivo shRNA screening identifies synthetic cytotoxicity in CREBBP/EP300 mutant head and neck cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-978
Abstract: The p300-CBP1 coactivator family members (CREB-binding protein (CREBBP) and E1A binding protein p300 (EP300)) share significant homology and act as transcriptional co-activators for a large number of target genes. These genes are collectively mutated in… read more here.
Keywords: crebbp; ep300; crebbp ep300; hpv ... See more keywords
Abstract 6064: Discovery of potent and selective EP300 degraders with anti-cancer activity
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-6064
Abstract: E1A binding protein (EP300) and CREB binding protein (CBP) are paralog histone acetyltransferases involved in many cellular processes via their activity as transcriptional co-activators. Dysregulation of one or both proteins has been implicated in various… read more here.
Keywords: cancer; potent selective; discovery potent; ep300 ... See more keywords
Targeting Histone Acetyltransferase Gene Inactivation in Diffuse Large B Cell Lymphoma
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-117542
Abstract: Diffuse Large B-cell Lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma, accounting for ~30% of de-novo diagnoses and also arising as a frequent clinical evolution of indolent lymphomas. Although curable in a substantial… read more here.
Keywords: crebbp; lymphoma; ep300; dlbcl ... See more keywords
Aspirin induces autophagy via inhibition of the acetyltransferase EP300
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25364
Abstract: Aspirin (acetylsalicylate) is the chemically synthesized prodrug of salicylate and is therapeutic used since the end of the 19th century. Until nowadays, aspirin is one the most widely used medications globally. As for many other… read more here.
Keywords: ep300; inhibition; aspirin; salicylate ... See more keywords
EP300 contributes to high-altitude adaptation in Tibetans by regulating nitric oxide production
Sign Up to like & getrecommendations! Published in 2017 at "Zoological Research"
DOI: 10.24272/j.issn.2095-8137.2017.036
Abstract: The genetic adaptation of Tibetans to high altitude hypoxia likely involves a group of genes in the hypoxic pathway, as suggested by earlier studies. To test the adaptive role of the previously reported candidate gene… read more here.
Keywords: nitric oxide; ep300; adaptation tibetans; high altitude ... See more keywords
EP300 through upregulating the expression of vimentin to promote the progression of chordoma.
Sign Up to like & getrecommendations! Published in 2024 at "Neurosurgical focus"
DOI: 10.3171/2024.2.focus244
Abstract: OBJECTIVE There is a lack of effective drugs to treat the progression and recurrence of chordoma, which is widely resistant to treatment in chemotherapy. The authors investigated the functional and therapeutic relevance of the E1A-binding… read more here.
Keywords: ep300; progression; chordoma; expression vimentin ... See more keywords
The protective role of EP300 in monocrotaline-induced pulmonary hypertension
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2023.1037217
Abstract: Background Pulmonary hypertension (PH) is a lethal disease characterized by pulmonary vascular remodeling, which is mediated by the abnormal proliferation/migration of pulmonary arterial smooth muscle cells (PASMCs). Recent reports suggest the involvement of histone acetylation… read more here.
Keywords: mct induced; pulmonary hypertension; ep300; ep300 promoter ... See more keywords
Five novel EP300 variants expand the genetic and phenotypic spectrum of Rubinstein–Taybi syndrome type 2 in Chinese patients
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2025.1690693
Abstract: Introduction Rubinstein-Taybi syndrome type 2 (RSTS2; OMIM #613684) is a rare autosomal dominant disorder caused by loss-of-function variants in the EP300 gene (OMIM #602700), characterized by intellectual disability, distinctive craniofacial features, and skeletal anomalies. Methods… read more here.
Keywords: rubinstein taybi; syndrome type; taybi syndrome; ep300 ... See more keywords
Knockdown of MIR9-3HG inhibits proliferation and promotes apoptosis of cervical cancer cells by miR-498 via EP300
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2021.12388
Abstract: Cervical cancer is a serious gynecological cancer and one of the primary causes of mortality in female patients with cancer. Despite advances in cancer research, the molecular mechanism underlying cancer remains poorly understood. High levels… read more here.
Keywords: ep300; cervical cancer; mir9 3hg; proliferation ... See more keywords