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Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-95133-0
Abstract: Rubinstein–Taybi syndrome (RSTS) is a human genetic disorder characterized by distinctive craniofacial features, broad thumbs and halluces, and intellectual disability. Mutations in the CREB binding protein (CREBBP) and E1A binding protein p300 (EP300) are the…
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Keywords:
ep300;
plau;
ep300 plau;
rubinstein taybi ... See more keywords
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Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abl4618
Abstract: EP300, a transcription coactivator important in proliferation and differentiation, is frequently mutated in diverse cancer types, including small cell lung cancer (SCLC). While these mutations are thought to result in loss of EP300 function, the…
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Keywords:
cell;
ep300;
domain;
kix domain ... See more keywords
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Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-978
Abstract: The p300-CBP1 coactivator family members (CREB-binding protein (CREBBP) and E1A binding protein p300 (EP300)) share significant homology and act as transcriptional co-activators for a large number of target genes. These genes are collectively mutated in…
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Keywords:
crebbp;
ep300;
crebbp ep300;
hpv ... See more keywords
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Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-117542
Abstract: Diffuse Large B-cell Lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma, accounting for ~30% of de-novo diagnoses and also arising as a frequent clinical evolution of indolent lymphomas. Although curable in a substantial…
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Keywords:
crebbp;
lymphoma;
ep300;
dlbcl ... See more keywords
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Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25364
Abstract: Aspirin (acetylsalicylate) is the chemically synthesized prodrug of salicylate and is therapeutic used since the end of the 19th century. Until nowadays, aspirin is one the most widely used medications globally. As for many other…
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Keywords:
ep300;
inhibition;
aspirin;
salicylate ... See more keywords
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Published in 2017 at "Zoological Research"
DOI: 10.24272/j.issn.2095-8137.2017.036
Abstract: The genetic adaptation of Tibetans to high altitude hypoxia likely involves a group of genes in the hypoxic pathway, as suggested by earlier studies. To test the adaptive role of the previously reported candidate gene…
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Keywords:
nitric oxide;
ep300;
adaptation tibetans;
high altitude ... See more keywords
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Published in 2023 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2023.1037217
Abstract: Background Pulmonary hypertension (PH) is a lethal disease characterized by pulmonary vascular remodeling, which is mediated by the abnormal proliferation/migration of pulmonary arterial smooth muscle cells (PASMCs). Recent reports suggest the involvement of histone acetylation…
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Keywords:
mct induced;
pulmonary hypertension;
ep300;
ep300 promoter ... See more keywords
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Published in 2021 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2021.12388
Abstract: Cervical cancer is a serious gynecological cancer and one of the primary causes of mortality in female patients with cancer. Despite advances in cancer research, the molecular mechanism underlying cancer remains poorly understood. High levels…
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Keywords:
ep300;
cervical cancer;
mir9 3hg;
proliferation ... See more keywords