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Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30198
Abstract: Primary cilia have been found to function as mechanosensors in low‐magnitude high‐frequency vibration (LMHFV)‐induced osteogenesis. The PGE2 also regulates bone homeostasis and mechanical osteogenesis through its receptor EP4 signaling, but its involvement in LMHFV‐induced or…
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Keywords:
cox2 pge2;
ep4 signaling;
lmhfv;
primary cilia ... See more keywords
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1
Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2020.100871
Abstract: Human prostaglandin E2 receptor 4 (EP4) is one of the four subtypes of prostaglandin E2 (PGE2) receptors and belongs to the rhodopsin-type G protein-coupled receptor (GPCR) family. Particularly, EP4 is expressed in various cancer cells…
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Keywords:
receptor ep4;
prostaglandin receptor;
human prostaglandin;
receptor ... See more keywords
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3
Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4835
Abstract: Introduction: EP4 is one of the prostaglandin E2 (PGE2) receptors. We previously reported that EP4 promoted cell migration via Ca2+ signaling, however the underlying mechanism has remained unclear. In Ca2+ signaling, Store-operated Ca2+entry (SOCE) is…
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Keywords:
oral cancer;
ep4;
cell migration;
cancer ... See more keywords
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1
Published in 2019 at "Hypertension"
DOI: 10.1161/hyp.74.suppl_1.p2019
Abstract: The binding of prorenin to the (pro)renin receptor (PRR) stimulates MAPK/ERK1/2, cyclooxygenase-2 (COX-2), NOX-4-dependent production of reactive oxygen species (ROS), transforming growth factor-β (TGF-β), pro-fibrotic factors connecting tissue growth factor (CTGF), and plasminogen activator inhibitor…
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Keywords:
cox;
pro renin;
smad pathway;
receptor ... See more keywords
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Published in 2022 at "Physiological Reports"
DOI: 10.14814/phy2.15212
Abstract: Type 2 diabetes (T2D) affects >30 million Americans and nearly 70% of individuals with T2D will die from cardiovascular disease (CVD). Circulating levels of the inflammatory signaling lipid, prostaglandin E2 (PGE2), are elevated in the…
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Keywords:
function;
pge2;
prostaglandin pge2;
pge2 receptors ... See more keywords
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Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.01518
Abstract: Background: The purpose of this study is to elucidate mechanism(s) by which the orally active PGI2 analog, Beraprost (BPS), ameliorates pulmonary hypertension (PH). Prostaglandins are an important treatment for PH. Mechanisms of their action are…
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Keywords:
pulmonary hypertension;
mechanism;
receptor;
sensitive channels ... See more keywords
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Published in 2021 at "Cancers"
DOI: 10.3390/cancers13061410
Abstract: Simple Summary Within this study we investigated the expression of EP4 in vulvar cancer, its correlation with clinic-pathological parameters, its association with overall survival, and the effect oft EP4 antagonism on vulvar cancer cells, aiming…
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Keywords:
ep4;
expression;
cancer;
vulvar cancer ... See more keywords