Crosstalk between the COX2‐PGE2‐EP4 signaling pathway and primary cilia in osteoblasts after mechanical stimulation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30198
Abstract: Primary cilia have been found to function as mechanosensors in low‐magnitude high‐frequency vibration (LMHFV)‐induced osteogenesis. The PGE2 also regulates bone homeostasis and mechanical osteogenesis through its receptor EP4 signaling, but its involvement in LMHFV‐induced or… read more here.
Keywords: cox2 pge2; ep4 signaling; lmhfv; primary cilia ... See more keywords
Functional expression of human prostaglandin E2 receptor 4 (EP4) in E. coli and characterization of the binding property of EP4 with Gα proteins
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2020.100871
Abstract: Human prostaglandin E2 receptor 4 (EP4) is one of the four subtypes of prostaglandin E2 (PGE2) receptors and belongs to the rhodopsin-type G protein-coupled receptor (GPCR) family. Particularly, EP4 is expressed in various cancer cells… read more here.
Keywords: receptor ep4; prostaglandin receptor; human prostaglandin; receptor ... See more keywords
SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2407130121
Abstract: Significance Specialized pro-resolving mediators (SPMs) are poly-unsaturated fatty acid derivatives, which have anti-inflammatory and pro-resolving properties. However, their mechanism of action is still unclear. Here, we report that major synthetic SPMs function as positive allosteric… read more here.
Keywords: receptor; inflammatory pro; pro resolving; positive allosteric ... See more keywords
Abstract 4835: EP4 increases the mitochondrial respiration and promotes cell migration in oral cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4835
Abstract: Introduction: EP4 is one of the prostaglandin E2 (PGE2) receptors. We previously reported that EP4 promoted cell migration via Ca2+ signaling, however the underlying mechanism has remained unclear. In Ca2+ signaling, Store-operated Ca2+entry (SOCE) is… read more here.
Keywords: oral cancer; ep4; cell migration; cancer ... See more keywords
Abstract P2019: (Pro)Renin Receptor-Dependent Induction of Pro-Fibrotic Factors is Mediated by COX-2/EP4/NOX-4/Smad Pathway in Mouse Renal Collecting Duct Cells
Sign Up to like & getrecommendations! Published in 2019 at "Hypertension"
DOI: 10.1161/hyp.74.suppl_1.p2019
Abstract: The binding of prorenin to the (pro)renin receptor (PRR) stimulates MAPK/ERK1/2, cyclooxygenase-2 (COX-2), NOX-4-dependent production of reactive oxygen species (ROS), transforming growth factor-β (TGF-β), pro-fibrotic factors connecting tissue growth factor (CTGF), and plasminogen activator inhibitor… read more here.
Keywords: cox; pro renin; smad pathway; receptor ... See more keywords
Pharmacological modulation of prostaglandin E2 (PGE2) EP receptors improves cardiomyocyte function under hyperglycemic conditions
Sign Up to like & getrecommendations! Published in 2022 at "Physiological Reports"
DOI: 10.14814/phy2.15212
Abstract: Type 2 diabetes (T2D) affects >30 million Americans and nearly 70% of individuals with T2D will die from cardiovascular disease (CVD). Circulating levels of the inflammatory signaling lipid, prostaglandin E2 (PGE2), are elevated in the… read more here.
Keywords: function; pge2; prostaglandin pge2; pge2 receptors ... See more keywords
Mechanism of Beraprost Effects on Pulmonary Hypertension: Contribution of Cross-Binding to PGE2 Receptor 4 and Modulation of O2 Sensitive Voltage-Gated K+ Channels
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.01518
Abstract: Background: The purpose of this study is to elucidate mechanism(s) by which the orally active PGI2 analog, Beraprost (BPS), ameliorates pulmonary hypertension (PH). Prostaglandins are an important treatment for PH. Mechanisms of their action are… read more here.
Keywords: pulmonary hypertension; mechanism; receptor; sensitive channels ... See more keywords
EP4 as a Negative Prognostic Factor in Patients with Vulvar Cancer
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DOI: 10.3390/cancers13061410
Abstract: Simple Summary Within this study we investigated the expression of EP4 in vulvar cancer, its correlation with clinic-pathological parameters, its association with overall survival, and the effect oft EP4 antagonism on vulvar cancer cells, aiming… read more here.
Keywords: ep4; expression; cancer; vulvar cancer ... See more keywords