The microRNA-7-mediated reduction in EPAC-1 contributes to vascular endothelial permeability and eNOS uncoupling in murine experimental retinopathy
Sign Up to like & getrecommendations! Published in 2017 at "Acta Diabetologica"
DOI: 10.1007/s00592-017-0985-y
Abstract: AbstractAims To investigate the consequences of oxidative stress and hypoxia on EPAC-1 expression during retinopathy.MethodsOxygen-induced retinopathy was induced in mice and EPAC-1 expression investigated by immunofluorescence. In silico analyses were used to identify a link… read more here.
Keywords: endothelial permeability; epac expression; expression; epac ... See more keywords
Estrogen increases expression of vascular alpha 2C adrenoceptor through the cAMP/Epac/JNK/AP-1 pathway and potentiates cold-induced vasoconstriction.
Sign Up to like & getrecommendations! Published in 2020 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2020.106690
Abstract: Cutaneous cold-induced vasoconstriction is a normal physiological reaction mediated by alpha 2C-adrenergic receptors (α2C-ARs) expressed in vascular smooth muscle cells (VSMCs). When this reaction is exaggerated, Raynaud's phenomenon (RP) ensues. RP is more prevalent in… read more here.
Keywords: induced vasoconstriction; jnk; cold induced; estrogen ... See more keywords
The Potentially Therapeutic Role of EPAC in Curbing the Process of Idiopathic Pulmonary Fibrosis via Differential Cellular Pathways
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s296382
Abstract: Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrosis disease caused by genetic susceptibility (causative) and other indirect risk factors such as smoking, micro-aspiration and air pollution. Repeated damage of lung epithelial cells can… read more here.
Keywords: role; fibrosis; epac; pulmonary fibrosis ... See more keywords