Epac1 regulates TLR4 signaling in the diabetic retinal vasculature.
Sign Up to like & getrecommendations! Published in 2021 at "Cytokine"
DOI: 10.1016/j.cyto.2021.155576
Abstract: Toll-like receptor 4 (TLR4) polymorphisms occur in diabetic patients. Previous work showed that TLR4 is in the retina of diabetic mice, as well as in retinal endothelial cells (REC) and Müller cells. Since we have… read more here.
Keywords: epac1; mice; tlr4 signaling; signaling diabetic ... See more keywords
Epac1 – a tonic stabilizer of the endothelial barrier
Sign Up to like & getrecommendations! Published in 2017 at "Acta Physiologica"
DOI: 10.1111/apha.12738
Abstract: The elegant study of Kopperud et al. in this issue of Acta Physiologica entitled ‘Increased microvascular permeability in mice lacking Epac1 (Rapgef3)’ addresses the role of Epac1 for maintenance of endothelial barrier properties. During the… read more here.
Keywords: barrier; camp; endothelial barrier; epac1 ... See more keywords
Pharmacological Inhibition of Epac1 Averts Ferroptosis Cell Death by Preserving Mitochondrial Integrity
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11020314
Abstract: Exchange proteins directly activated by cAMP (Epac) proteins are implicated in a wide range of cellular functions including oxidative stress and cell survival. Mitochondrial-dependent oxidative stress has been associated with progressive neuronal death underlying the… read more here.
Keywords: cell death; cell; inhibition; epac1 ... See more keywords