Long non-coding RNA ZFAS1 promotes the expression of EPAS1 in gastric cardia adenocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Advanced Research"
DOI: 10.1016/j.jare.2020.06.006
Abstract: Graphical abstract The hypoxia microenvironment induces the expression of HIF1 and EPAS1 in GCA. During tumor development, the EPAS1 suppresses the expression of HIF1, resulting in the dominant form of HIFs switching from HIF1 to… read more here.
Keywords: long non; non coding; hif1 epas1; coding rna ... See more keywords
A pleiotropic hypoxia-sensitive EPAS1 enhancer is disrupted by adaptive alleles in Tibetans
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.ade1942
Abstract: In Tibetans, noncoding alleles in EPAS1—whose protein product hypoxia-inducible factor 2α (HIF-2α) drives the response to hypoxia—carry strong signatures of positive selection; however, their functional mechanism has not been systematically examined. Here, we report that… read more here.
Keywords: sensitive epas1; hypoxia sensitive; epas1; pleiotropic hypoxia ... See more keywords