LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "epas1" as a keyword



Photo from archive.org

Long non-coding RNA ZFAS1 promotes the expression of EPAS1 in gastric cardia adenocarcinoma

Sign Up to like & get
recommendations! Published in 2021 at "Journal of Advanced Research"

DOI: 10.1016/j.jare.2020.06.006

Abstract: Graphical abstract The hypoxia microenvironment induces the expression of HIF1 and EPAS1 in GCA. During tumor development, the EPAS1 suppresses the expression of HIF1, resulting in the dominant form of HIFs switching from HIF1 to… read more here.

Keywords: long non; non coding; hif1 epas1; coding rna ... See more keywords

A pleiotropic hypoxia-sensitive EPAS1 enhancer is disrupted by adaptive alleles in Tibetans

Sign Up to like & get
recommendations! Published in 2022 at "Science Advances"

DOI: 10.1126/sciadv.ade1942

Abstract: In Tibetans, noncoding alleles in EPAS1—whose protein product hypoxia-inducible factor 2α (HIF-2α) drives the response to hypoxia—carry strong signatures of positive selection; however, their functional mechanism has not been systematically examined. Here, we report that… read more here.

Keywords: sensitive epas1; hypoxia sensitive; epas1; pleiotropic hypoxia ... See more keywords

Akkermansia muciniphila alleviates abdominal aortic aneurysms via restoring CITED2 activated by EPAS1

Sign Up to like & get
recommendations! Published in 2024 at "Infection and Immunity"

DOI: 10.1128/iai.00172-24

Abstract: ABSTRACT Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease that has been linked to gut microbiome dysbiosis. Therefore, this study aims to investigate the effects of Akkermansia muciniphila (Am) on AAA mice and the… read more here.

Keywords: aaa mice; muciniphila alleviates; akkermansia muciniphila; abdominal aortic ... See more keywords

EPAS-1-related pheochromocytoma/paraganglioma: How common and how aggressive?

Sign Up to like & get
recommendations! Published in 2024 at "Endocrine-related cancer"

DOI: 10.1530/erc-23-0303

Abstract: In 2012, somatic EPAS1 pathogenic variants were found to cause a triad of pheochromocytoma/paragangliomas (PPGL), polycythemia and somatostatinoma. Since then, a limited number of studies on this subject have been reported and data on the… read more here.

Keywords: epas1; epas1 related; epas1 pathogenic; ppgl ... See more keywords