A pleiotropic hypoxia-sensitive EPAS1 enhancer is disrupted by adaptive alleles in Tibetans
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.ade1942
Abstract: In Tibetans, noncoding alleles in EPAS1—whose protein product hypoxia-inducible factor 2α (HIF-2α) drives the response to hypoxia—carry strong signatures of positive selection; however, their functional mechanism has not been systematically examined. Here, we report that… read more here.
Keywords: sensitive epas1; hypoxia sensitive; epas1; pleiotropic hypoxia ... See more keywords