Comprehensive epithelial biomarker analysis of malignant mesothelioma: EpCAM positivity is a potential diagnostic pitfall.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer cytopathology"
DOI: 10.1002/cncy.22706
Abstract: BACKGROUND Epithelial cell adhesion molecule (EpCAM) is frequently used to distinguish carcinoma from background mesothelial cells during cytologic examination of body cavity fluids. Previously, the authors identified one malignant mesothelioma case with strong and diffuse… read more here.
Keywords: epcam; epcam positivity; malignant mesothelioma; biomarker ... See more keywords
The EpCAM overexpression is associated with clinicopathological significance and prognosis in hepatocellular carcinoma patients: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of surgery"
DOI: 10.1016/j.ijsu.2018.06.025
Abstract: BACKGROUND Hepatocellular carcinoma (HCC) is one of most common causes for cancer-related death around the world. Epithelial cell adhesion molecule (EpCAM) is established as a vital prognostic factor for the human malignant tumors. However, the… read more here.
Keywords: associated clinicopathological; overexpression; hcc; epcam ... See more keywords
Sensitive electrochemical aptasensor for detecting EpCAM with silica nanoparticles and quantum dots for signal amplification
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Electroanalytical Chemistry"
DOI: 10.1016/j.jelechem.2019.113655
Abstract: Abstract The epithelial cell adhesion molecule (EpCAM) is a known biomarker of circulating tumor cells that plays an important role in tumor metastasis. The detection of EpCAM is vital for personalized diagnosis and therapy but… read more here.
Keywords: aptasensor; silica nanoparticles; electrochemical aptasensor; epcam ... See more keywords
Bone Marrow-Derived Cells Contribute to the Maintenance of Thymic Stroma including TECs
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/6061746
Abstract: In paradox to critical functions for T-cell selection and self-tolerance, the thymus undergoes profound age-associated atrophy and loss of T-cell function, further enhanced by cancer therapies. Identifying thymic epithelial progenitor populations capable of forming functional… read more here.
Keywords: thymic stroma; bone marrow; epcam; cd45 epcam ... See more keywords
EGFR-Dependent Regulated Intramembrane Proteolysis of EpCAM-Letter.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-16-2456
Abstract: Hsu and colleagues reported on EGF/EGFR–triggered activation of regulated intramembrane proteolysis (RIP) of EpCAM that induces an EMT phenotype ([1][1]). This finding is of utmost interest, as it might explain contradicting effects of EpCAM on… read more here.
Keywords: egfr dependent; dependent regulated; intramembrane proteolysis; epcam ... See more keywords
Abstract 3364: Combined enrichment of plasma EpCAM-positive extracellular vesicles (EVs) and circulating tumor cells (CTCs) from a single tube of cancer patient blood samples, for subsequent molecular analysis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3364
Abstract: Background: EVs are secreted by cells in physiological and pathological conditions and carry selected molecules, such as proteins, DNA and RNA; specific EVs released by neoplastic cells are defined as “tumor-derived extracellular vesicles (tdEVs)”. tdEVs… read more here.
Keywords: plasma; analysis; epcam; blood ... See more keywords
Diagnostic Value of Epithelial Cell Adhesion Molecule Flow Cytometry for Diagnosis of Metastatic Carcinoma in Serous Effusions.
Sign Up to like & getrecommendations! Published in 2023 at "Acta cytologica"
DOI: 10.1159/000528061
Abstract: INTRODUCTION Malignant serous effusions are common in metastatic carcinomas. Although cytomorphology is recognized as the gold standard diagnostic method, it exhibits moderate sensitivity. This study aimed to assess the diagnostic value of immunophenotyping with a… read more here.
Keywords: epcam; diagnostic value; flow cytometry; cytology ... See more keywords
EPCAM and TROP2 share a role in claudin stabilization and development of intestinal and extraintestinal epithelia in mice
Sign Up to like & getrecommendations! Published in 2022 at "Biology Open"
DOI: 10.1242/bio.059403
Abstract: ABSTRACT Epithelial cell adhesion molecule (EPCAM) is a transmembrane glycoprotein expressed on the surface of most epithelial and epithelium-derived tumor cells and reported to regulate stability of epithelial tight junction proteins, claudins. Despite its widespread… read more here.
Keywords: development intestinal; trop2; epcam trop2; mice ... See more keywords
Cytosolic EpCAM cooperates with H-Ras to regulate epithelial to mesenchymal transition through ZEB1
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0285707
Abstract: Next generation sequencing of human cancer mutations has identified novel therapeutic targets. Activating Ras oncogene mutations play a central role in oncogenesis, and Ras-driven tumorigenesis upregulates an array of genes and signaling cascades that can… read more here.
Keywords: epcam l240a; mesenchymal transition; expression; epithelial mesenchymal ... See more keywords
EpCAM as a Predictive Marker of Tumor Recurrence and Survival in Patients Who Underwent Surgical Resection for Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "AntiCancer Research"
DOI: 10.21873/anticanres.12700
Abstract: Background/Aim: Epithelial cell adhesion molecule (EpCAM) is expressed in hepatic progenitor cells and hepatocellular carcinoma (HCC), and is considered a marker of liver cancer stem cells. Materials and Methods: A total of 262 patients were… read more here.
Keywords: tumor recurrence; surgical resection; epcam; tumor ... See more keywords
rs62139665 Polymorphism in the Promoter Region of EpCAM Is Associated With Hepatitis C Virus-Related Hepatocellular Carcinoma Risk in Egyptians
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.754104
Abstract: Hepatocellular carcinoma (HCC) is a universal health problem that is particularly alarming in Egypt. The major risk factor for HCC is hepatitis C virus (HCV) infection which is a main burden in Egypt. The epithelial… read more here.
Keywords: hepatocellular carcinoma; polymorphism; hcc; risk ... See more keywords