Anti-Epcam Aptamer (Syl3c)-Functionalized Liposome for Targeted Delivery Of Doxorubicin: In Vitro And In Vivo Antitumor Studies in Mice Bearing C26 Colon Carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale Research Letters"
DOI: 10.1186/s11671-020-03334-9
Abstract: In this study, we have surface-functionalized PEGylated-nanoliposomal doxorubicin (DOX) with anti-EpCAM (epithelial cell adhesion molecule) aptamer via post-insertion of anti-EpCAM aptamer-conjugated DSPE-mPEG 2000 into Caelyx® (ED-lip). The size, charge, release profile, and cytotoxicity and cellular… read more here.
Keywords: c26; anti epcam; lip; epcam aptamer ... See more keywords
Transforming doxorubicin into a cancer stem cell killer via EpCAM aptamer-mediated delivery
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DOI: 10.7150/thno.20168
Abstract: Chemotherapy-resistant cancer stem cells (CSCs) are a major obstacle to the effective treatment of many forms of cancer. To overcome CSC chemo-resistance, we developed a novel system by conjugating a CSC-targeting EpCAM aptamer with doxorubicin… read more here.
Keywords: cancer; epcam aptamer; csc; cancer stem ... See more keywords