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   Articles with "epcr" as a keyword



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Astragaloside IV inhibits PMA-induced EPCR shedding through MAPKs and PKC pathway

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recommendations! Published in 2017 at "Immunopharmacology and Immunotoxicology"

DOI: 10.1080/08923973.2017.1306868

Abstract: Abstract Astragaloside IV (AS-IV), a main active substance isolated from Astragalus membranaceus Bunge, has been shown to have multiple pharmacological effects. Endothelial cell protein C receptor (EPCR) is a marker of inflammation, and is also… read more here.

Keywords: induced epcr; pma induced; pkc pathway; epcr ... See more keywords
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Endothelial microparticles released by activated protein C protect beta cells through EPCR/PAR1 and annexin A1/FPR2 pathways in islets

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recommendations! Published in 2017 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.13191

Abstract: Islet transplantation is associated with early ischaemia/reperfusion, localized coagulation and redox‐sensitive endothelial dysfunction. In animal models, islet cytoprotection by activated protein C (aPC) restores islet vascularization and protects graft function, suggesting that aPC triggers various… read more here.

Keywords: protein; epcr; endothelial microparticles; annexin ... See more keywords

PP18 Implementation of electronic patient clinical records in ambulances in the UK: a national survey

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recommendations! Published in 2019 at "Emergency Medicine Journal"

DOI: 10.1136/emermed-2019-999.18

Abstract: Background The roll-out of electronic Patient Clinical Records (ePCR) across UK ambulance services has been an important aspect of modernisation. Electronic Records in Ambulances (ERA) is a two-year study which aims to describe the opportunities… read more here.

Keywords: implementation; epcr; patient clinical; clinical records ... See more keywords
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EPCR: a novel marker of cultured cord blood HSCs.

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recommendations! Published in 2017 at "Blood"

DOI: 10.1182/blood-2017-05-780007

Abstract: In this issue of Blood , Fares et al 1 demonstrate that endothelial protein C receptor (EPCR) is a reliable marker of human cord blood (CB) hematopoietic stem cells (HSCs), both from uncultured cells and… read more here.

Keywords: hscs; cord blood; epcr; blood ... See more keywords

Factor VIIa induces extracellular vesicles from the endothelium: A potential mechanism for its hemostatic effect.

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recommendations! Published in 2021 at "Blood"

DOI: 10.1182/blood.2020008417

Abstract: Recombinant FVIIa (rFVIIa) is used as a hemostatic agent to treat bleeding disorders in hemophilia patients with inhibitors and other groups of patients. Our recent studies showed that FVIIa binds endothelial cell protein C receptor… read more here.

Keywords: extracellular vesicles; fviia; par1; epcr ... See more keywords
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Factor VIIa interaction with EPCR modulates the hemostatic effect of rFVIIa in hemophilia therapy: Mode of its action.

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recommendations! Published in 2017 at "Blood advances"

DOI: 10.1182/bloodadvances.2016004143

Abstract: Recent studies established that clotting factor VIIa (FVIIa) binds endothelial cell protein C receptor (EPCR). It has been speculated that FVIIa interaction with EPCR might augment the hemostatic effect of rFVIIa in therapeutic conditions. The… read more here.

Keywords: epcr; hemostatic effect; effect rfviia; interaction epcr ... See more keywords