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   Articles with "ependymoma" as a keyword



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Heterogeneity within the PF-EPN-B ependymoma subgroup

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recommendations! Published in 2018 at "Acta Neuropathologica"

DOI: 10.1007/s00401-018-1888-x

Abstract: Posterior fossa ependymoma comprise three distinct molecular variants, termed PF-EPN-A (PFA), PF-EPN-B (PFB), and PF-EPN-SE (subependymoma). Clinically, they are very disparate and PFB tumors are currently being considered for a trial of radiation avoidance. However,… read more here.

Keywords: pfb tumors; heterogeneity; posterior fossa; heterogeneity within ... See more keywords
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TERT promoter mutation and chromosome 6 loss define a high-risk subtype of ependymoma evolving from posterior fossa subependymoma

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recommendations! Published in 2021 at "Acta Neuropathologica"

DOI: 10.1007/s00401-021-02300-8

Abstract: Subependymomas are benign tumors characteristically encountered in the posterior fossa of adults that show distinct epigenetic profiles assigned to the molecular group “subependymoma, posterior fossa” (PFSE) of the recently established DNA methylation-based classification of central… read more here.

Keywords: mixed tumors; posterior fossa; ependymoma; subependymoma ... See more keywords
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Intramedullary ependymoma: long-term outcome after surgery

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recommendations! Published in 2017 at "Acta Neurochirurgica"

DOI: 10.1007/s00701-017-3430-7

Abstract: BackgroundOverall (OS) and progression-free survival (PFS) of patients undergoing spinal ependymoma resection has been frequently reported. Contrarily, OS and PFS of purely intramedullary ependymomas have not been clearly determined yet.MethodsThe data of 37 patients undergoing… read more here.

Keywords: intramedullary ependymoma; long term; term outcome; ependymoma ... See more keywords
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Into Thin Air: Hypoxia Drives Metabolic and Epigenomic Deregulation of Lethal Pediatric Ependymoma.

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recommendations! Published in 2020 at "Developmental cell"

DOI: 10.1016/j.devcel.2020.06.020

Abstract: Posterior fossa type A (PFA) ependymoma is a lethal pediatric brain tumor proposed to be driven solely by epigenetic deregulation. Michealraj et al. (2020) demonstrate that hypoxia reprograms PFA metabolism and, subsequently, the epigenome toward H3K27… read more here.

Keywords: air hypoxia; lethal pediatric; ependymoma; deregulation ... See more keywords
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Rare Giant Intradural Extramedullary Ependymoma.

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recommendations! Published in 2018 at "World neurosurgery"

DOI: 10.1016/j.wneu.2017.12.069

Abstract: A 23-year-old female was admitted to our hospital because she had suffered from back pain for 3 years and paralysis of both lower limbs for 10 days. Neurologic examination showed sensory disturbance and complete paralysis… read more here.

Keywords: intradural extramedullary; rare giant; giant intradural; ependymoma ... See more keywords
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Microsurgical Resection of an Intramedullary Ependymoma at the Cervicomedullary Junction: A 2-Dimensional Operative Video.

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recommendations! Published in 2020 at "World neurosurgery"

DOI: 10.1016/j.wneu.2020.05.201

Abstract: Ependymomas are the most common adult intramedullary spinal tumors.1 Although uncommon in the brainstem, ependymomas make up a large proportion of tumors of this location.2-8 We present an operative video case report of an intrinsic… read more here.

Keywords: ependymoma cervicomedullary; ependymoma; operative video; resection intramedullary ... See more keywords
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YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-11884-5

Abstract: YAP1 fusion-positive supratentorial ependymomas predominantly occur in infants, but the molecular mechanisms of oncogenesis are unknown. Here we show YAP1-MAMLD1 fusions are sufficient to drive malignant transformation in mice, and the resulting tumors share histo-molecular… read more here.

Keywords: ependymoma; yap1 mamld1; fusion; factor ... See more keywords
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Retinal Ependymoma: A Rare Extra-Axial Presentation

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recommendations! Published in 2020 at "American Journal of Clinical Pathology"

DOI: 10.1093/ajcp/aqaa161.068

Abstract: Ependymomas are well-demarcated and slow-growing neuroepithelial neoplasms that comprise 3–9% of primary CNS tumors. The vast majority of ependymomas arise either intracranially, mostly in children, or in the spinal cord and are associated with ependymal… read more here.

Keywords: ependymoma rare; cell processes; ependymoma; rare extra ... See more keywords
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European genetic ancestry associated with risk of childhood ependymoma.

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recommendations! Published in 2020 at "Neuro-oncology"

DOI: 10.1093/neuonc/noaa130

Abstract: BACKGROUND Ependymoma is a histologically defined central nervous system tumor most commonly occurring in childhood. Population-level incidence differences by race/ethnicity are observed, with individuals of European ancestry at highest risk. We aimed to determine whether… read more here.

Keywords: risk; genetic ancestry; ependymoma; european genetic ... See more keywords
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EPEN-30. C11ORF95-RELA FUSION PROTEIN ENGAGES NOVEL GENOMIC LOCI TO DRIVE MURINE EPENDYMOMA GROWTH

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recommendations! Published in 2020 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaa222.166

Abstract: Abstract RATIONALE Over 70% of supratentorial (ST) ependymoma are characterized by an oncogenic fusion between C11ORF95 and RELA. C11ORF95-RELA fusion is frequently the sole genetic driver detected in ST ependymoma, thus ranking this genomic event… read more here.

Keywords: rela; ependymoma; c11orf95 rela; rela fusion ... See more keywords
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EPEN-35. PERITONEAL CARCINOMATOSIS OF ANAPLASTIC EPENDYMOMA: FIRST REPORTED CASE

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recommendations! Published in 2020 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaa222.170

Abstract: Abstract Peritoneal Carcinomatosis of anaplastic ependymoma is not a previously reported entity. The authors report on a child with multiple successfully treated brain and spine disease occurrences who subsequently develops carcinomatosis of the abdomen and… read more here.

Keywords: peritoneal carcinomatosis; carcinomatosis; ependymoma; anaplastic ependymoma ... See more keywords