SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2105562
Abstract: ABSTRACT Glioblastoma multiforme (GBM) is the most common brain malignancy insensitive to radiotherapy (RT). Although macroautophagy/autophagy was reported to be a fundamental factor prolonging the survival of tumors under radiotherapeutic stress, the autophagic biomarkers coordinated… read more here.
Keywords: fusion autophagosomes; tgm2; autophagosomes lysosomes; gbm ... See more keywords
The role of ectopic P granules protein 5 homolog (EPG5) in DHPG‐induced pain sensitization in mice
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15779
Abstract: Nociplastic pain is a severe health problem, while its mechanisms are still unclear. (R, S)‐3,5‐Dihydroxyphenylglycine (DHPG) is a group I metabotropic glutamate receptor (mGluR) agonist that can cause central sensitization, which plays a role in… read more here.
Keywords: role; sensitization; ectopic granules; mice ... See more keywords