Eph and ephrin signaling in the development of the central auditory system
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.506
Abstract: Acoustic communication relies crucially on accurate interpretation of information about the intensity, frequency, timing, and location of diverse sound stimuli in the environment. To meet this demand, neurons along different levels of the auditory system… read more here.
Keywords: auditory system; development; central auditory; eph ephrin ... See more keywords
Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica"
DOI: 10.1007/s00401-019-02011-1
Abstract: Schwann cells (SC) enter the central nervous system (CNS) in pathophysiological conditions. However, how SC invade the CNS to remyelinate central axons remains undetermined. We studied SC migratory behavior ex vivo and in vivo after… read more here.
Keywords: eph ephrin; ephrin signaling; migration; blood ... See more keywords
Targeting Eph/ephrin system in cancer therapy.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.07.029
Abstract: It is well established that the Eph/ephrin system plays a central role in the embryonic development, with minor implications in the physiology of the adult. However, it is overexpressed and deregulated in a variety of… read more here.
Keywords: eph ephrin; system; ephrin system; targeting eph ... See more keywords
Getting direction(s): The Eph/ephrin signaling system in cell positioning.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental biology"
DOI: 10.1016/j.ydbio.2018.01.012
Abstract: In vertebrates, the Eph/ephrin family of signaling molecules is a large group of membrane-bound proteins that signal through a myriad of mechanisms and effectors to play diverse roles in almost every tissue and organ system.… read more here.
Keywords: eph ephrin; system; direction eph; ephrin signaling ... See more keywords
EPH-ective control of cytokinesis
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2016.1251230
Abstract: Experimental evidence in the unicellular choanoflagellate Salpingoeca rosetta, the closest living relative of animals, proposes that emergence of multicellularity – one of the founding step of animal life – is caused by incomplete separation of… read more here.
Keywords: eph ephrin; cytokinesis; eph; ephrin signaling ... See more keywords
Protection by the Eph–Ephrin System Against Mesenteric Ischemia-Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2017 at "SHOCK"
DOI: 10.1097/shk.0000000000000890
Abstract: ABSTRACT Mesenteric ischemia-reperfusion (I/R)-induced injury targets primarily endothelial and epithelial cells, leading to a cascade of inflammatory events, eventually culminating in life-threatening syndromes. Hitherto, the role of Eph, the largest family of tyrosine kinase receptors,… read more here.
Keywords: eph ephrin; mesenteric ischemia; ephrin system; ephrin ... See more keywords
UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25272
Abstract: Glioblastoma multiforme (GBM) is the most malignant brain tumor, showing high resistance to standard therapeutic approaches that combine surgery, radiotherapy, and chemotherapy. As opposed to healthy tissues, EphA2 has been found highly expressed in specimens… read more here.
Keywords: eph ephrin; glioblastoma; small molecule; molecule targeting ... See more keywords
Roles of Eph-Ephrin Signaling in the Eye Lens Cataractogenesis, Biomechanics, and Homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.852236
Abstract: The eye lens is responsible for fine focusing of light onto the retina, and its function relies on tissue transparency and biomechanical properties. Recent studies have demonstrated the importance of Eph-ephrin signaling for the maintenance… read more here.
Keywords: eye lens; ephrin signaling; eph ephrin; homeostasis ... See more keywords
The EPH/Ephrin System in Bone and Soft Tissue Sarcomas’ Pathogenesis and Therapy: New Advancements and a Literature Review
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23095171
Abstract: Musculoskeletal sarcomas represent rare heterogenous malignancies of mesenchymal origin that can be divided in two distinct subtypes, bone and soft tissue sarcomas. Current treatment options combine the surgical excision of local tumors and multidrug chemotherapy… read more here.
Keywords: bone soft; soft tissue; eph ephrin; tissue sarcomas ... See more keywords
The EPH/Ephrin System in Pancreatic Ductal Adenocarcinoma (PDAC): From Pathogenesis to Treatment
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24033015
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a major concern for health care systems worldwide, since its mortality remains unaltered despite the surge in cutting-edge science. The EPH/ephrin signaling system was first investigated in the 1980s. EPH/ephrins… read more here.
Keywords: system; eph ephrin; ephrin system; pancreatic ductal ... See more keywords
UniPR1331: Small Eph/Ephrin Antagonist Beneficial in Intestinal Inflammation by Interfering with Type-B Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceuticals"
DOI: 10.3390/ph14060502
Abstract: Eph receptors, comprising A and B classes, interact with cell-bound ephrins generating bidirectional signaling. Although mainly related to carcinogenesis and organogenesis, the role of Eph/ephrin system in inflammation is growingly acknowledged. Recently, we showed that… read more here.
Keywords: eph ephrin; type signaling; ephrin antagonist; epha ephrin ... See more keywords