Eph and ephrin signaling in the development of the central auditory system
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.506
Abstract: Acoustic communication relies crucially on accurate interpretation of information about the intensity, frequency, timing, and location of diverse sound stimuli in the environment. To meet this demand, neurons along different levels of the auditory system… read more here.
Keywords: auditory system; development; central auditory; eph ephrin ... See more keywords
Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica"
DOI: 10.1007/s00401-019-02011-1
Abstract: Schwann cells (SC) enter the central nervous system (CNS) in pathophysiological conditions. However, how SC invade the CNS to remyelinate central axons remains undetermined. We studied SC migratory behavior ex vivo and in vivo after… read more here.
Keywords: eph ephrin; ephrin signaling; migration; blood ... See more keywords
Targeting Eph/ephrin system in cancer therapy.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.07.029
Abstract: It is well established that the Eph/ephrin system plays a central role in the embryonic development, with minor implications in the physiology of the adult. However, it is overexpressed and deregulated in a variety of… read more here.
Keywords: eph ephrin; system; ephrin system; targeting eph ... See more keywords
Getting direction(s): The Eph/ephrin signaling system in cell positioning.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental biology"
DOI: 10.1016/j.ydbio.2018.01.012
Abstract: In vertebrates, the Eph/ephrin family of signaling molecules is a large group of membrane-bound proteins that signal through a myriad of mechanisms and effectors to play diverse roles in almost every tissue and organ system.… read more here.
Keywords: eph ephrin; system; direction eph; ephrin signaling ... See more keywords
EPH-ective control of cytokinesis
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2016.1251230
Abstract: Experimental evidence in the unicellular choanoflagellate Salpingoeca rosetta, the closest living relative of animals, proposes that emergence of multicellularity – one of the founding step of animal life – is caused by incomplete separation of… read more here.
Keywords: eph ephrin; cytokinesis; eph; ephrin signaling ... See more keywords
Protection by the Eph–Ephrin System Against Mesenteric Ischemia-Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2017 at "SHOCK"
DOI: 10.1097/shk.0000000000000890
Abstract: ABSTRACT Mesenteric ischemia-reperfusion (I/R)-induced injury targets primarily endothelial and epithelial cells, leading to a cascade of inflammatory events, eventually culminating in life-threatening syndromes. Hitherto, the role of Eph, the largest family of tyrosine kinase receptors,… read more here.
Keywords: eph ephrin; mesenteric ischemia; ephrin system; ephrin ... See more keywords
UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25272
Abstract: Glioblastoma multiforme (GBM) is the most malignant brain tumor, showing high resistance to standard therapeutic approaches that combine surgery, radiotherapy, and chemotherapy. As opposed to healthy tissues, EphA2 has been found highly expressed in specimens… read more here.
Keywords: eph ephrin; glioblastoma; small molecule; molecule targeting ... See more keywords
Roles of Eph-Ephrin Signaling in the Eye Lens Cataractogenesis, Biomechanics, and Homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.852236
Abstract: The eye lens is responsible for fine focusing of light onto the retina, and its function relies on tissue transparency and biomechanical properties. Recent studies have demonstrated the importance of Eph-ephrin signaling for the maintenance… read more here.
Keywords: eye lens; ephrin signaling; eph ephrin; homeostasis ... See more keywords
Eph/ephrin-mediated immune modulation: a potential therapeutic target
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1539567
Abstract: Eph/ephrin signaling, a complex network of cell-cell interactions, plays a pivotal role in regulating various biological processes, including cell migration, proliferation, and adhesion. Dysregulation of this signaling pathway has been implicated in various types of… read more here.
Keywords: eph ephrin; cell; tumor; ephrin signaling ... See more keywords
Beyond cell-cell contact: therapeutic potential of Eph signaling in central nervous system tumors
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2025.1658651
Abstract: Eph receptor tyrosine kinases and their membrane-bound ephrin ligands constitute a unique bidirectional signaling system that orchestrates cell adhesion, migration, proliferation, and vascular patterning, processes frequently co-opted in malignancy. We conducted an integrative review of… read more here.
Keywords: receptor; system; central nervous; nervous system ... See more keywords
Potential role of the Eph/ephrin system in colorectal cancer: emerging druggable molecular targets
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2024.1275330
Abstract: The Eph/ephrin system regulates many developmental processes and adult tissue homeostasis. In colorectal cancer (CRC), it is involved in different processes including tumorigenesis, tumor angiogenesis, metastasis development, and cancer stem cell regeneration. However, conflicting data… read more here.
Keywords: eph ephrin; colorectal cancer; ephrin system; role ... See more keywords