Ephrin (Eph) receptor and downstream signaling pathways: a promising potential targeted therapy for COVID‑19 and associated cancers and diseases
Sign Up to like & getrecommendations! Published in 2022 at "Human Cell"
DOI: 10.1007/s13577-022-00697-2
Abstract: Currently, the coronavirus disease 2019 (COVID-19) pandemic has become a serious concern to the worldwide healthcare system. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for COVID-19 and the emergence of new SARS-CoV-2 variants such… read more here.
Keywords: ephrin; receptor; eph receptor; downstream signaling ... See more keywords
Eph receptor signalling: from catalytic to non-catalytic functions
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DOI: 10.1038/s41388-019-0931-2
Abstract: Eph receptors, the largest subfamily of receptor tyrosine kinases, are linked with proliferative disease, such as cancer, as a result of their deregulated expression or mutation. Unlike other tyrosine kinases that have been clinically targeted,… read more here.
Keywords: receptor signalling; non catalytic; eph receptor; eph receptors ... See more keywords
The Roles of EphB2 in Cancer
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DOI: 10.3389/fcell.2022.788587
Abstract: The erythropoietin-producing hepatocellular carcinoma (Eph) receptors and their Eph receptor-interacting (ephrin) ligands together constitute a vital cell communication system with diverse roles. Experimental evidence revealed Eph receptor bidirectional signaling with both tumor-promoting and tumor-suppressing activities… read more here.
Keywords: cancer; tumor; ephb2 cancer; roles ephb2 ... See more keywords
The EphB6 Receptor: Kinase-Dead but Very Much Alive
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DOI: 10.3390/ijms22158211
Abstract: The Eph receptor tyrosine kinase member EphB6 is a pseudokinase, and similar to other pseudoenzymes has not attracted an equivalent amount of interest as its enzymatically-active counterparts. However, a greater appreciation for the role pseudoenzymes… read more here.
Keywords: ephb6 receptor; eph receptor; kinase dead; kinase ... See more keywords