Eph receptors as cancer targets for antibody-based therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in cancer research"
DOI: 10.1016/bs.acr.2020.04.007
Abstract: Receptor tyrosine kinases (RTKs) are integral membrane sensors that govern cell differentiation, proliferation and mobility, and enable rapid communication between cells and their environment. Of the 20 RTK subfamilies currently known, Eph receptors are the… read more here.
Keywords: antibody based; eph receptors; receptors cancer; cancer targets ... See more keywords
Eph receptor signalling: from catalytic to non-catalytic functions
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-0931-2
Abstract: Eph receptors, the largest subfamily of receptor tyrosine kinases, are linked with proliferative disease, such as cancer, as a result of their deregulated expression or mutation. Unlike other tyrosine kinases that have been clinically targeted,… read more here.
Keywords: receptor signalling; non catalytic; eph receptor; eph receptors ... See more keywords
The Functions of EphA1 receptor tyrosine kinase in Several Tumors.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220820125638
Abstract: BACKGROUND Eph receptors tyrosine kinase (RTK) were identified in 1987 from hepatocellular carcinoma cell lines and were the largest known subfamily of RTK. Eph receptors can be divided into two categories, EphA and EphB, based… read more here.
Keywords: eph receptors; epha1; treatment; receptor ... See more keywords
Eph Receptors in Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11020315
Abstract: Eph receptor tyrosine kinases play critical functions during development, in the formation of tissue and organ borders, and the vascular and neural systems. Uniquely among tyrosine kinases, their activities are controlled by binding to membrane-bound… read more here.
Keywords: eph receptors; development; receptors cancer;
Drug Conjugates for Targeting Eph Receptors in Glioblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceuticals"
DOI: 10.3390/ph13040077
Abstract: Glioblastoma (GBM) is a complex and heterogeneous tumor that warrants a comprehensive therapeutic approach for treatment. Tumor-associated antigens offer an opportunity to selectively target various components of the GBM microenvironment while sparing the normal cells… read more here.
Keywords: drug conjugates; eph receptors; targeting eph; conjugates targeting ... See more keywords
Antibody Targeting of Eph Receptors in Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceuticals"
DOI: 10.3390/ph13050088
Abstract: The Eph subfamily of receptor tyrosine kinases mediate cell-cell communication controlling cell and tissue patterning during development. While generally less active in adult tissues, they often re-emerge in cancers, particularly on undifferentiated or progenitor cells… read more here.
Keywords: eph receptors; antibody targeting; targeting eph; receptors cancer ... See more keywords