Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112083
Abstract: The EphA2 receptor has been validated in animal models as new target for treating tumors depending on angiogenesis and vasculogenic mimicry. In the present work, we extended our current knowledge on structure-activity relationship (SAR) data… read more here.
Keywords: antagonists based; optimization epha2; based lithocholic; epha2 ... See more keywords
Epha2 genotype influences ultraviolet radiation induced cataract in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.107806
Abstract: Age-related cataract is the major cause of blindness worldwide. Both genetic and environmental factors contribute to the disease. Genetic variation in the Ephrin type-A receptor 2 (EPHA2) gene is associated with the risk of age-related… read more here.
Keywords: epha2; epha2 mice; ultraviolet radiation; cataract mice ... See more keywords
Novel [111In]In-BnDTPA-EphA2-230-1 Antibody for Single-Photon Emission Computed Tomography Imaging Tracer Targeting of EphA2
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c07849
Abstract: Erythropoietin-producing hepatocellular receptor A2 (EphA2) is overexpressed in cancer cells and causes abnormal cell proliferation. Therefore, it has attracted attention as a target for diagnostic agents. In this study, the EphA2-230-1 monoclonal antibody (EphA2-230-1) was… read more here.
Keywords: 111in bndtpa; epha2 230; bndtpa epha2; imaging tracer ... See more keywords
Eicosapentaenoic acid in combination with EPHA2 inhibition shows efficacy in preclinical models of triple-negative breast cancer by disrupting cellular cholesterol efflux
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0569-5
Abstract: Triple-negative breast cancer (TNBC), the most aggressive breast cancer subtype, currently lacks effective targeted therapy options. Eicosapentaenoic acid (EPA), an omega-3 fatty acid and constituent of fish oil, is a common supplement with anti-inflammatory properties.… read more here.
Keywords: inhibition; epha2; breast cancer; cancer ... See more keywords
Restored microRNA-519a enhances the radiosensitivity of non-small cell lung cancer via suppressing EphA2
Sign Up to like & getrecommendations! Published in 2021 at "Gene Therapy"
DOI: 10.1038/s41434-020-00213-x
Abstract: Accumulating evidence has demonstrated that microRNA-519a (miR-519a) acts as the tumor suppressor in various cancers, but little is known regarding its intrinsic regulatory mechanisms in non-small cell lung cancer (NSCLC). Here, we aimed to investigate… read more here.
Keywords: radiosensitivity; microrna 519a; mir 519a; epha2 ... See more keywords
Aggressive and recurrent ovarian cancers upregulate ephrinA5, a non-canonical effector of EphA2 signaling duality
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-88382-6
Abstract: Erythropoietin producing hepatocellular (Eph) receptors and their membrane-bound ligands ephrins are variably expressed in epithelial cancers, with context-dependent implications to both tumor-promoting and -suppressive processes in ways that remain incompletely understood. Using ovarian cancer tissue… read more here.
Keywords: epha2; aggressive recurrent; ovarian cancers; recurrent ovarian ... See more keywords
CircPAG1 inhibits the high glucose-induced lens epithelial cell injury by sponging miR-630 and upregulating EPHA2.
Sign Up to like & getrecommendations! Published in 2021 at "Current eye research"
DOI: 10.1080/02713683.2021.1933058
Abstract: BACKGROUND : Circular RNAs (circRNAs) have been considered as vital regulators in the progression of human ocular diseases, including diabetic cataract (DC). This report was designed to research the biological role of circRNA phosphoprotein associated… read more here.
Keywords: cell injury; lens epithelial; circpag1; epha2 ... See more keywords
Ligand‐independent EphA2 contributes to chemoresistance in small‐cell lung cancer by enhancing PRMT1‐mediated SOX2 methylation
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15653
Abstract: Chemoresistance is the crux of clinical treatment failure of small‐cell lung cancer (SCLC). Cancer stem cells play a critical role in therapeutic resistance of malignant tumors. Studies have shown that the role of erythropoietin‐producing hepatocellular… read more here.
Keywords: ligand independent; small cell; prmt1; epha2 ... See more keywords
Influence of miR‐520e‐mediated MAPK signalling pathway on HBV replication and regulation of hepatocellular carcinoma cells via targeting EphA2
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Viral Hepatitis"
DOI: 10.1111/jvh.13048
Abstract: We determined the role of miR‐520e in the replication of hepatitis B virus (HBV) and the growth of hepatocellular carcinoma (HCC) cells. MiR‐520e and EPH receptor A2 (EphA2) in HBV‐positive HCC tissues and cells were… read more here.
Keywords: hepatocellular carcinoma; epha2; hbv replication; mir 520e ... See more keywords
Abstract 1235: EPHA2-targeted therapy enhances the cytotoxicity of eicosapentaenoic acid against triple-negative inflammatory breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-1235
Abstract: Background: Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer. We have previously reported that mediators of inflammation, such as COX-2, promote the growth of Triple-Negative receptor (TN) IBC xenografts; therefore, inflammation… read more here.
Keywords: epha2; breast cancer; inflammatory; cancer ... See more keywords
microRNA-451a promoter methylation regulated by DNMT3B expedites bladder cancer development via the EPHA2/PI3K/AKT axis
Sign Up to like & getrecommendations! Published in 2020 at "BMC Cancer"
DOI: 10.1186/s12885-020-07523-8
Abstract: Background The downregulation of microRNA (miR)-451a has been reported in bladder cancer (BCa) tissues. Herein, we elucidated the role of miR-451a in BCa with the involvement of DNA methyltransferase 3B (DNMT3B). Methods We first screened… read more here.
Keywords: methylation; bca; epha2; mir 451a ... See more keywords