Ephrin‐A1‐EphA4 signaling negatively regulates myelination in the central nervous system
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23293
Abstract: During development of the central nervous system not all axons are myelinated, and axons may have distinct myelination patterns. Furthermore, the number of myelin sheaths formed by each oligodendrocyte is highly variable. However, our current… read more here.
Keywords: epha4; nervous system; central nervous; myelination ... See more keywords
Ephrin (Eph) receptor and downstream signaling pathways: a promising potential targeted therapy for COVID‑19 and associated cancers and diseases
Sign Up to like & getrecommendations! Published in 2022 at "Human Cell"
DOI: 10.1007/s13577-022-00697-2
Abstract: Currently, the coronavirus disease 2019 (COVID-19) pandemic has become a serious concern to the worldwide healthcare system. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for COVID-19 and the emergence of new SARS-CoV-2 variants such… read more here.
Keywords: ephrin; receptor; eph receptor; downstream signaling ... See more keywords
Ephrin-A2 regulates excitatory neuron differentiation and interneuron migration in the developing neocortex
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-12185-x
Abstract: The development of the neocortex requires co-ordination between proliferation and differentiation, as well as the precise orchestration of neuronal migration. Eph/ephrin signaling is crucial in guiding neurons and their projections during embryonic development. In adult… read more here.
Keywords: regulates excitatory; ephrin; ephrin signaling; migration ... See more keywords
Protection by the Eph–Ephrin System Against Mesenteric Ischemia-Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2017 at "SHOCK"
DOI: 10.1097/shk.0000000000000890
Abstract: ABSTRACT Mesenteric ischemia-reperfusion (I/R)-induced injury targets primarily endothelial and epithelial cells, leading to a cascade of inflammatory events, eventually culminating in life-threatening syndromes. Hitherto, the role of Eph, the largest family of tyrosine kinase receptors,… read more here.
Keywords: eph ephrin; mesenteric ischemia; ephrin system; ephrin ... See more keywords
Natural loss of function of ephrin-B3 shapes spinal flight circuitry in birds
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abg5968
Abstract: Spinal circuitry that enables wing flapping in birds evolved via genetic alternations of a guidance molecule. Flight in birds evolved through patterning of the wings from forelimbs and transition from alternating gait to synchronous flapping.… read more here.
Keywords: natural loss; ephrin; flight; function ... See more keywords
Nephrin-Binding Ephrin-B1 at the Slit Diaphragm Controls Podocyte Function through the JNK Pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2017090993
Abstract: Background B-type ephrins are membrane-bound proteins that maintain tissue function in several organs. We previously reported that ephrin-B1 is localized at the slit diaphragm of glomerular podocytes. However, the function of ephrin-B1 at this location… read more here.
Keywords: ephrin; jnk; phosphorylation; slit diaphragm ... See more keywords
Ligand-Dependent and Ligand-Independent Effects of Ephrin-B2–EphB4 Signaling in Melanoma Metastatic Spine Disease
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22158028
Abstract: Tumor–endothelial cell interactions represent an essential mechanism in spinal metastasis. Ephrin-B2–EphB4 communication induces tumor cell repulsion from the endothelium in metastatic melanoma, reducing spinal bone metastasis formation. To shed further light on the Ephrin-B2–EphB4 signaling… read more here.
Keywords: melanoma; endothelial ephrin; ephrin; metastasis ... See more keywords
Ephrin-B3 modulates hippocampal neurogenesis and the reelin signaling pathway in a pilocarpine-induced model of epilepsy
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2018.3543
Abstract: Ephrin-B3 is important in the regulation of cell proliferation, differentiation and migration via cell-cell contact, and can activate the reelin pathway during brain development. However, the effect of ephrin-B3 on hippocampal neurogenesis and the reelin… read more here.
Keywords: epilepsy; reelin pathway; hippocampal neurogenesis; ephrin ... See more keywords