Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica"
DOI: 10.1007/s00401-019-02011-1
Abstract: Schwann cells (SC) enter the central nervous system (CNS) in pathophysiological conditions. However, how SC invade the CNS to remyelinate central axons remains undetermined. We studied SC migratory behavior ex vivo and in vivo after… read more here.
Keywords: eph ephrin; ephrin signaling; migration; blood ... See more keywords
Location, Location, Location: EphB4:Ephrin-B2 Signaling Depends on Its Spatial Arrangement.
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical journal"
DOI: 10.1016/j.bpj.2018.07.014
Abstract: Cells have a challenge in crowded environments. They need to send specific messages to their nearest neighbors but not to cells two or three doorsteps away. This is a common problem in cell-to-cell communication that… read more here.
Keywords: location; ephb4 ephrin; location ephb4; ephrin signaling ... See more keywords
Getting direction(s): The Eph/ephrin signaling system in cell positioning.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental biology"
DOI: 10.1016/j.ydbio.2018.01.012
Abstract: In vertebrates, the Eph/ephrin family of signaling molecules is a large group of membrane-bound proteins that signal through a myriad of mechanisms and effectors to play diverse roles in almost every tissue and organ system.… read more here.
Keywords: eph ephrin; system; direction eph; ephrin signaling ... See more keywords
Ephrin-A2 regulates excitatory neuron differentiation and interneuron migration in the developing neocortex
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-12185-x
Abstract: The development of the neocortex requires co-ordination between proliferation and differentiation, as well as the precise orchestration of neuronal migration. Eph/ephrin signaling is crucial in guiding neurons and their projections during embryonic development. In adult… read more here.
Keywords: regulates excitatory; ephrin; ephrin signaling; migration ... See more keywords
Inhibition of EphA/Ephrin-A signaling using genetic and pharmacologic approaches improves recovery following traumatic brain injury in mice
Sign Up to like & getrecommendations! Published in 2019 at "Brain Injury"
DOI: 10.1080/02699052.2019.1641622
Abstract: ABSTRACT Primary Objective: Eph/Ephrin signaling is inhibitory for developing axons and blocking Eph pathways enhances regeneration after spinal cord injury. It was hypothesized that inhibition of Eph signaling promotes cellular and behavioral recovery after traumatic… read more here.
Keywords: traumatic brain; ephrin signaling; mice; brain injury ... See more keywords
EPH-ective control of cytokinesis
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2016.1251230
Abstract: Experimental evidence in the unicellular choanoflagellate Salpingoeca rosetta, the closest living relative of animals, proposes that emergence of multicellularity – one of the founding step of animal life – is caused by incomplete separation of… read more here.
Keywords: eph ephrin; cytokinesis; eph; ephrin signaling ... See more keywords
Notch-mediated Ephrin signaling disrupts islet architecture and β cell function.
Sign Up to like & getrecommendations! Published in 2022 at "JCI insight"
DOI: 10.1172/jci.insight.157694
Abstract: Altered islet architecture is associated with β cell dysfunction and Type 2 Diabetes (T2D) progression, but molecular effectors of islet spatial organization remain mostly unknown. Although Notch signaling is known to regulate pancreatic development, we… read more here.
Keywords: ephrin signaling; cell; islet architecture; notch ... See more keywords
Roles of Eph-Ephrin Signaling in the Eye Lens Cataractogenesis, Biomechanics, and Homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.852236
Abstract: The eye lens is responsible for fine focusing of light onto the retina, and its function relies on tissue transparency and biomechanical properties. Recent studies have demonstrated the importance of Eph-ephrin signaling for the maintenance… read more here.
Keywords: eye lens; ephrin signaling; eph ephrin; homeostasis ... See more keywords