Targeting Eph/ephrin system in cancer therapy.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.07.029
Abstract: It is well established that the Eph/ephrin system plays a central role in the embryonic development, with minor implications in the physiology of the adult. However, it is overexpressed and deregulated in a variety of… read more here.
Keywords: eph ephrin; system; ephrin system; targeting eph ... See more keywords
Protection by the Eph–Ephrin System Against Mesenteric Ischemia-Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2017 at "SHOCK"
DOI: 10.1097/shk.0000000000000890
Abstract: ABSTRACT Mesenteric ischemia-reperfusion (I/R)-induced injury targets primarily endothelial and epithelial cells, leading to a cascade of inflammatory events, eventually culminating in life-threatening syndromes. Hitherto, the role of Eph, the largest family of tyrosine kinase receptors,… read more here.
Keywords: eph ephrin; mesenteric ischemia; ephrin system; ephrin ... See more keywords
Potential role of the Eph/ephrin system in colorectal cancer: emerging druggable molecular targets
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2024.1275330
Abstract: The Eph/ephrin system regulates many developmental processes and adult tissue homeostasis. In colorectal cancer (CRC), it is involved in different processes including tumorigenesis, tumor angiogenesis, metastasis development, and cancer stem cell regeneration. However, conflicting data… read more here.
Keywords: eph ephrin; colorectal cancer; ephrin system; role ... See more keywords
The EPH/Ephrin System in Pancreatic Ductal Adenocarcinoma (PDAC): From Pathogenesis to Treatment
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24033015
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a major concern for health care systems worldwide, since its mortality remains unaltered despite the surge in cutting-edge science. The EPH/ephrin signaling system was first investigated in the 1980s. EPH/ephrins… read more here.
Keywords: system; eph ephrin; ephrin system; pancreatic ductal ... See more keywords