A novel compound EPIC-0412 reverses temozolomide resistance via inhibiting DNA repair/MGMT in glioblastoma.
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DOI: 10.1093/neuonc/noac242
Abstract: BACKGROUND TMZ resistance has become an important obstacle affecting its therapeutic benefits. O6-methylguanine DNA methyltransferase (MGMT) is primarily responsible for the TMZ resistance in GBM patients. Additionally, active DNA damage repair pathways can also lead… read more here.
Keywords: epic 0412; epic; dna damage; resistance ... See more keywords