Corneous beta proteins of the epidermal differentiation complex (EDC) form large part of the corneous material of claws and rhamphothecae in turtles
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DOI: 10.1007/s00709-020-01494-0
Abstract: The presence of specific protein types in claws and beaks of turtles is poorly known. The present immunological study describes the localization of some of the main corneous beta proteins (CBPs) coded in the epidermal… read more here.
Keywords: corneous beta; epidermal differentiation; sub unguis; material ... See more keywords
Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation
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DOI: 10.1038/s41467-019-10020-7
Abstract: The presence and absence of RNA modifications regulates RNA metabolism by modulating the binding of writer, reader, and eraser proteins. For 5-methylcytosine (m5C) however, it is largely unknown how it recruits or repels RNA-binding proteins.… read more here.
Keywords: epidermal differentiation; vault; derived small; differentiation ... See more keywords
Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake
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DOI: 10.1038/s41598-019-39770-6
Abstract: Preclinical studies frequently lack predictive value for human conditions. Human cell-based disease models that reflect patient heterogeneity may reduce the high failure rates of preclinical research. Herein, we investigated the impact of primary cell age… read more here.
Keywords: epidermal differentiation; differentiation drug; differentiation; homeostasis epidermal ... See more keywords
CDK12 Is Necessary to Promote Epidermal Differentiation Through Transcription Elongation.
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DOI: 10.1093/stmcls/sxac002
Abstract: Proper differentiation of the epidermis is essential to prevent water loss and to protect the body from the outside environment. Perturbations in this process can lead to a variety of skin diseases that impacts 1… read more here.
Keywords: cdk12; epidermal differentiation; elongation; transcription elongation ... See more keywords
Monitoring calcium-induced epidermal differentiation in vitro using multiphoton microscopy
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DOI: 10.1117/1.jbo.25.7.071205
Abstract: Abstract. Significance: Research in tissue engineering and in vitro organ formation has recently intensified. To assess tissue morphology, the method of choice today is restricted primarily to histology. Thus novel tools are required to enable… read more here.
Keywords: microscopy; epidermal differentiation; vitro; tissue ... See more keywords
Lipocalin 2 Participates in the Epidermal Differentiation and Inflammatory Processes of Psoriasis
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DOI: 10.2147/jir.s358492
Abstract: Abstract As a multifunctional cytokine, lipocalin 2 is weakly expressed in skin and serum under normal conditions. However, it is over-expressed by neutrophils and keratinocytes in the skin lesions and sera in several skin diseases.… read more here.
Keywords: epidermal differentiation; lipocalin participates; differentiation inflammatory; participates epidermal ... See more keywords
Fuzhenghefuzhiyang Formula (FZHFZY) Improves Epidermal Differentiation via Suppression of the Akt/mTORC1/S6K1 Signalling Pathway in Psoriatic Models
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DOI: 10.3389/fphar.2021.650816
Abstract: Psoriasis is a chronic proliferative skin disorder characterised by abnormal epidermal differentiation. The Fuzhenghefuzhiyang (FZHFZY) formula created by Chuanjian Lu, a master of Chinese medicine in dermatology, has been external used in the Guangdong Provincial… read more here.
Keywords: fzhfzy; epidermal differentiation; differentiation; psoriasis ... See more keywords
Carboxamide Derivatives Are Potential Therapeutic AHR Ligands for Restoring IL-4 Mediated Repression of Epidermal Differentiation Proteins
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DOI: 10.3390/ijms23031773
Abstract: Atopic dermatitis (AD) is a common T-helper 2 (Th2) lymphocyte-mediated chronic inflammatory skin disease characterized by disturbed epidermal differentiation (e.g., filaggrin (FLG) expression) and diminished skin barrier function. Therapeutics targeting the aryl hydrocarbon receptor (AHR),… read more here.
Keywords: epidermal differentiation; differentiation proteins; mediated repression; differentiation ... See more keywords
Epigenetic Mechanisms of Epidermal Differentiation
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DOI: 10.3390/ijms23094874
Abstract: Keratinocyte differentiation is an essential process for epidermal stratification and stratum corneum formation. Keratinocytes proliferate in the basal layer of the epidermis and start their differentiation by changing their functional or phenotypical type; this process… read more here.
Keywords: epidermal differentiation; keratinocyte differentiation; epidermal development; mechanisms epidermal ... See more keywords