A novel 2-oxopyrrolidine derivative (LN-53) efficiently induces Nrf-2 signaling pathway activation in human epidermal keratinocytes
Sign Up to like & getrecommendations! Published in 2025 at "Pharmacological Reports"
DOI: 10.1007/s43440-025-00757-y
Abstract: The skin is a pivotal organ that serves as a physical barrier, protecting the body from harmful substances such as pathogens, allergens, and other environmental irritants. Chronic inflammation in the skin, along with the anthropogenic… read more here.
Keywords: activation; human epidermal; epidermal keratinocytes; nrf signaling ... See more keywords
Understanding the implications of engineered nanoparticle induced autophagy in human epidermal keratinocytes in vitro
Sign Up to like & getrecommendations! Published in 2019 at "NanoImpact"
DOI: 10.1016/j.impact.2019.100177
Abstract: Abstract Engineered nanoparticles (NPs) such as TiO2 and ZnO are key UV-blocking ingredients in sunscreens. While toxicological risks of applying these materials are generally regarded as low due to minute levels of penetration across the… read more here.
Keywords: epidermal keratinocytes; engineered nanoparticle; implications engineered; human epidermal ... See more keywords
Toll-like receptor signaling induces the expression of lympho-epithelial Kazal-type inhibitor in epidermal keratinocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2018.09.001
Abstract: BACKGROUND Lympho-epithelial Kazal-type inhibitor (LEKTI) tightly controls the activities of serine proteases such as kallikrein-related peptidase (KLK) 5 and KLK7 in the epidermis. LEKTI is known to be an essential molecule for the epidermal skin… read more here.
Keywords: lekti; expression lekti; lympho epithelial; epidermal keratinocytes ... See more keywords
Decreased expression of suprabasin induces aberrant differentiation and apoptosis of epidermal keratinocytes: Possible role for atopic dermatitis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2019.07.009
Abstract: BACKGROUND Suprabasin (SBSN), a secreted protein, is expressed in various epithelial tissues. The role of SBSN in epidermal differentiation and atopic dermatitis (AD) pathology remains largely unknown. OBJECTIVE To evaluate the effects of SBSN on… read more here.
Keywords: apoptosis; epidermal keratinocytes; atopic dermatitis; expression ... See more keywords
TLR3 augments glucocorticoid-synthetic enzymes expression in epidermal keratinocytes; Implications of glucocorticoid metabolism in rosacea epidermis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2020.08.011
Abstract: BACKGROUND While most skin diseases benefit from topical steroids, rosacea symptoms are exacerbated by topical steroids. In the rosacea pathogenesis, abnormal innate immune mechanisms including overexpression of the Toll-like receptor (TLR) have been proposed. However,… read more here.
Keywords: synthetic enzymes; tlr3; epidermal keratinocytes; glucocorticoid synthetic ... See more keywords
GPNMB is expressed in human epidermal keratinocytes but disappears in the vitiligo lesional skin
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-61931-1
Abstract: GPNMB is involved in multiple cellular functions including cell adhesion, stress protection and stem cell maintenance. In skin, melanocyte-GPNMB is suggested to mediate pigmentation through melanosome formation, but details of keratinocyte-GPNMB have yet to be… read more here.
Keywords: epidermal keratinocytes; skin; human epidermal; expression ... See more keywords
Functionally expressed bitter taste receptor TAS2R14 in human epidermal keratinocytes serves as a chemosensory receptor
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Dermatology"
DOI: 10.1111/exd.14250
Abstract: Traditionally, it is theorized that skin sensation is initiated when cutaneous sensory afferents and Merkel cells receive sensory stimuli, while epidermal keratinocytes were deemed to have no role. However, mounting evidence has shown that keratinocytes… read more here.
Keywords: tas2r14; epidermal keratinocytes; chemosensory receptor; serves chemosensory ... See more keywords
Do epidermal keratinocytes have sensory and information processing systems?
Sign Up to like & getrecommendations! Published in 2021 at "Experimental dermatology"
DOI: 10.1111/exd.14494
Abstract: It was long considered that the role of epidermal keratinocytes is solely to construct a water-impermeable protective membrane, the stratum corneum, at the uppermost layer of the skin. However, in the last two decades, it… read more here.
Keywords: epidermal keratinocytes; processing systems; sensory information; keratinocytes sensory ... See more keywords
Reprogramming of epidermal keratinocytes by PITX1 transforms the cutaneous cellular landscape and promotes wound healing
Sign Up to like & getrecommendations! Published in 2024 at "JCI Insight"
DOI: 10.1172/jci.insight.182844
Abstract: Cutaneous wound healing is a slow process that often terminates with permanent scarring while oral wounds, in contrast, regenerate after damage faster. Unique molecular networks in epidermal and oral epithelial keratinocytes contribute to the tissue-specific… read more here.
Keywords: keratinocytes pitx1; reprogramming epidermal; oral keratinocyte; pitx1 transforms ... See more keywords
SIRT5 reduces the inflammatory response and barrier dysfunction in IL-17A-induced epidermal keratinocytes.
Sign Up to like & getrecommendations! Published in 2023 at "Allergologia et immunopathologia"
DOI: 10.15586/aei.v51i1.675
Abstract: Psoriasis is a chronic multisystemic inflammatory disease with inflammatory cell infiltration, hyperproliferation of keratinocytes in skin lesions, and epidermal barrier dysfunction. Normal human epidermal keratinocytes (NHEKs) were stimulated with interleukin 17A (IL-17A). The expression levels… read more here.
Keywords: barrier dysfunction; dysfunction 17a; keratinocytes sirt5; dysfunction ... See more keywords
Astragaloside IV suppresses the proliferation and inflammatory response of human epidermal keratinocytes and ameliorates imiquimod-induced psoriasis-like skin damage in mice.
Sign Up to like & getrecommendations! Published in 2024 at "Allergologia et immunopathologia"
DOI: 10.15586/aei.v52i5.1140
Abstract: The primary pathological features of psoriasis include excessive epidermal keratinocytes and infiltration of inflammatory cells, which are pivotal targets for psoriasis therapy. Astragaloside IV (AS-IV), the principal active compound of astragalus, exhibits anti-inflammatory, antioxidant, and… read more here.
Keywords: psoriasis like; like skin; induced psoriasis; human epidermal ... See more keywords