Epidermal Stem Cell‐Derived Extracellular Vesicles Induce Fibroblasts Mesenchymal‐Epidermal Transition to Alleviate Hypertrophic Scar Formation via miR‐200s Inhibition of ZEB1 and 2
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.70160
Abstract: ABSTRACT Hypertrophic scar (HS) is a prevalent yet unresolved wound healing complication characterized by persistent hyperactive and proliferative fibroblasts, leading to excessive extracellular matrix (ECM) synthesis and collagen contraction. Our previous studies have identified epidermal… read more here.
Keywords: extracellular vesicles; hypertrophic scar; mir 200s; epidermal transition ... See more keywords
Epidermal Stem Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-31206-0_12
Abstract: A multilayered epithelium to fulfil its function must be replaced throughout the lifespan. This is possible due to the presence of multipotent, self-renewing epidermal stem cells that give rise to differentiated cell lineages: keratinocytes, hairs,… read more here.
Keywords: cell; biology; epidermal stem; stem ... See more keywords
Preliminary studies of hair follicle regeneration by injections of epidermal stem cells and dermal papilla cells into nude mice
Sign Up to like & getrecommendations! Published in 2020 at "Cell and Tissue Banking"
DOI: 10.1007/s10561-020-09825-4
Abstract: The ultimate goal of organ regenerative therapy is to reproduce fully functional organs to replace which have been damaged as a result of diseases or injury. Although several studies claimed that using different types of… read more here.
Keywords: hair follicle; papilla cells; cells dermal; epidermal stem ... See more keywords
Laminin 332-Dependent YAP Dysregulation Depletes Epidermal Stem Cells in Junctional Epidermolysis Bullosa.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.04.055
Abstract: Laminin 332-deficient junctional epidermolysis bullosa (JEB) is a severe genetic skin disease. JEB is marked by epidermal stem cell depletion, the origin of which is unknown. We show that dysregulation of the YAP and TAZ… read more here.
Keywords: stem cells; jeb; yap; epidermal stem ... See more keywords
Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization.
Sign Up to like & getrecommendations! Published in 2021 at "Cell stem cell"
DOI: 10.1016/j.stem.2021.05.007
Abstract: Stem cells support lifelong maintenance of adult organs, but their specific roles during injury are poorly understood. Here we demonstrate that Lgr6 marks a regionally restricted population of epidermal stem cells that interact with nerves… read more here.
Keywords: stem cells; wound epithelialization; epidermal stem; stem ... See more keywords
Interplay between epidermal stem cell dynamics and dermal deformation
Sign Up to like & getrecommendations! Published in 2018 at "npj Computational Materials"
DOI: 10.1038/s41524-018-0101-z
Abstract: Tissue growth is a driving force of morphological changes in living systems. Whereas the buckling instability is known to play a crutial role for initiating spatial pattern formations in such growing systems, little is known… read more here.
Keywords: stem; basement membrane; epidermal stem; stem cell ... See more keywords
Spatio-temporal regulation of gene expression defines subpopulations of epidermal stem cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Society transactions"
DOI: 10.1042/bst20200740
Abstract: The search for epidermal stem cells has gained the momentum as they possess unique biological characteristics and a potential in regeneration therapies. Several transcription factors and miRNAs have been identified as epidermal stem cell markers.… read more here.
Keywords: epidermal stem; temporal regulation; spatio temporal; stem cells ... See more keywords
How and Why the Circadian Clock Regulates Proliferation of Adult Epithelial Stem Cells
Sign Up to like & getrecommendations! Published in 2023 at "Stem Cells"
DOI: 10.1093/stmcls/sxad013
Abstract: Abstract First described in the early 20th century, diurnal oscillations in stem cell proliferation exist in multiple internal epithelia, including in the gastrointestinal tract, and in the epidermis. In the mouse epidermis, 3- to 4-fold… read more here.
Keywords: circadian clock; proliferation; epidermal stem; stem ... See more keywords
Alterations in epidermal stem cells within the pilosebaceous unit in atrophic acne scars
Sign Up to like & getrecommendations! Published in 2024 at "Australasian Journal of Dermatology"
DOI: 10.1111/ajd.14224
Abstract: Atrophic acne scarring is a common sequela of inflammatory acne, causing significant problems for affected patients. Although prolonged inflammation and subsequent aberrant tissue regeneration are considered the underlying pathogenesis, the role of epidermal stem cells,… read more here.
Keywords: atrophic acne; stem cells; alterations epidermal; cells within ... See more keywords
The increase of interfollicular epidermal stem cells and regulation of aryl hydrocarbon receptor and its repressors in the skin through hydroporation with anti‐aging cocktail
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cosmetic Dermatology"
DOI: 10.1111/jocd.12798
Abstract: Hydroporation is a procedure that involves a subsonic flow of air and microdroplets into the skin. We previously reported that hydroporation treatment with a cocktail solution containing copper‐glycyl‐L‐histidyl‐L‐lysyl, oligo hyaluronic acid, rhodiola extract, tranexamic acid,… read more here.
Keywords: hydroporation; interfollicular epidermal; increase interfollicular; cells regulation ... See more keywords
Abstract 1799: Regulation of epidermal stem cell proliferation and adhesion by ACSS2
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-1799
Abstract: Acetyl-CoA Synthetase Short-Chain Family Member 2 (ACSS2) is an enzyme that converts acetate into acetyl-CoA, a crucial metabolite required for protein acetylation and lipogenesis. Acetyl-CoA is membrane-impermeable and must be synthesized in the compartment in… read more here.
Keywords: cell; proliferation adhesion; acss2; epidermal stem ... See more keywords