Human epididymis protein 4 is a useful predictor of post‐operative prognosis in patients with severe aortic stenosis
Sign Up to like & getrecommendations! Published in 2024 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14845
Abstract: The human epididymis protein 4 (HE4), a novel fibrosis marker, is expressed only in activated fibroblasts and is thought to reflect ongoing left ventricular (LV) fibrosis. LV fibrosis is a feature of severe aortic stenosis… read more here.
Keywords: severe aortic; post operative; operative prognosis; human epididymis ... See more keywords
Significantly elevated serum human epididymis protein‐4 in chronic kidney disease patients without ovarian cancer: A large‐scale retrospective study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24847
Abstract: Human epididymis protein‐4 (HE‐4) is a commonly used biomarker for diagnosing ovarian cancer. Elevated HE‐4 has also been observed in various benign conditions including chronic kidney disease (CKD); however, generalizability and statistical power of previous… read more here.
Keywords: epididymis protein; ovarian cancer; chronic kidney; human epididymis ... See more keywords
Targeting and neutralizing human epididymis protein 4 by novel nanobodies to suppress ovarian cancer cells and attenuate cisplatin resistance.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.01.015
Abstract: Human epididymis protein 4 (HE4) is a glycoprotein secreted by epithelial ovarian cancer (EOC) cells and is a novel and specific biomarker for diagnosing and prognosing EOC. Previous studies have shown that overexpression of HE4… read more here.
Keywords: epididymis protein; human epididymis; he4; anti he4 ... See more keywords
Clinical utility of human epididymis protein 4
Sign Up to like & getrecommendations! Published in 2025 at "Critical Reviews in Clinical Laboratory Sciences"
DOI: 10.1080/10408363.2025.2512467
Abstract: Abstract This review comprehensively elucidates the current clinical applications of human epididymis protein 4 (HE4) in various systemic diseases. Initially discovered in 1991 and linked to sperm maturation, HE4 has since been recognized for its… read more here.
Keywords: human epididymis; clinical utility; epididymis protein; he4 ... See more keywords
Prognostic values of human epididymis protein 4 expression in patients with endometrial cancer: A systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.15356
Abstract: There is no consensus on the correlation between human epididymis protein 4 (HE4) and prognosis of endometrial cancer (EC). Therefore, we performed a meta‐analysis to assess the relationship between HE4 and prognosis of EC. read more here.
Keywords: endometrial cancer; epididymis protein; meta analysis; human epididymis ... See more keywords