IL-33 Promotes ST2-Dependent Fibroblast Maturation via P38 and TGF-β in a Mouse Model of Epidural Fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "Tissue engineering and regenerative medicine"
DOI: 10.1007/s13770-021-00425-1
Abstract: BACKGROUND Recent evidence suggests that IL-33, a novel member of the IL-1β family, is involved in organ fibrosis. However, the roles of IL-33 and its receptor ST2 in epidural fibrosis post spine operation remain elusive.… read more here.
Keywords: tgf; maturation; p38 tgf; epidural fibrosis ... See more keywords
Artesunate inhibits fibroblasts proliferation and reduces surgery‐induced epidural fibrosis via the autophagy‐mediated p53/p21waf1/cip1 pathway
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.10.048
Abstract: Abstract Fibroblast proliferation is considered to be a major cause in the process of epidural fibrosis formation. Autophagy is a tightly‐regulated catabolic process in charge of degrading intracellular components. Although autophagy has been associated with… read more here.
Keywords: fibrosis; epidural fibrosis; proliferation; autophagy ... See more keywords
Evaluation of topical Dexmedetomidine administration in postlaminectomy epidural fibrosis rat model.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of surgery"
DOI: 10.1016/j.ijsu.2018.03.032
Abstract: Epidural fibrosis is a challenging topic in spinal surgery. Numerous clinical and experimental studies have been focused on this issue to clarify problems faced in spinal procedures for the patient as well as the surgeon… read more here.
Keywords: administration; fibrosis; epidural fibrosis; topical dex ... See more keywords
Dose preservation of ligament flavum really help prevent postoperative epidural fibrosis and improve outcome in microdiscectomy?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2020.06.013
Abstract: OBJECTIVE A prospective, randomized, controlled clinical study was conducted with surgery performed by the same surgeon. The aim was to present a new technique for preserving the ligament flavum during lumbar microdiscectomy, and to evaluate… read more here.
Keywords: prevent postoperative; fibrosis; epidural fibrosis; group ... See more keywords
Histopathologic Analysis of Tamoxifen on Epidural Fibrosis.
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DOI: 10.1016/j.wneu.2018.01.004
Abstract: BACKGROUND Epidural fibrosis is a challenging topic in spinal surgery. This phenomenon constitutes one of the main reasons behind postlaminectomy syndrome or failed back surgery syndrome, which leads to persistent back and leg pain in… read more here.
Keywords: fibrosis; epidural fibrosis; group; dural thickness ... See more keywords
Antifibrotic Effect of Boric Acid in Rats with Epidural Fibrosis.
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DOI: 10.1016/j.wneu.2018.10.187
Abstract: BACKGROUND Epidural fibrosis is a major problem after spine surgery, with some patients having recurrent symptoms secondary to excessive formation of scar tissue resulting in neurologic compression. We used a rat laminectomy model to determine… read more here.
Keywords: epidural fibrosis; effect boric; solution; boric acid ... See more keywords
Analysis of pain markers and epidural fibrosis caused by repeated spinal surgery in Sprague–Dawley rats
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DOI: 10.1186/s12891-020-03920-z
Abstract: Background Epidural fibrosis is one of the aetiologies of pain following a spinal revision surgery. It is reported that the specific members of the mitogen – activated protein kinases (MAPK) family might mediate neuropathic pain.… read more here.
Keywords: epidural fibrosis; group; expression; repeated surgeries ... See more keywords
Suberoylanilide hydroxamic acid attenuates epidural fibrosis via inhibiting myofibroblast differentiation and increasing fibroblast apoptosis.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202005_21364
Abstract: OBJECTIVE Epidural fibrosis represents a fatal stage of failed back surgery syndrome (FBSS) of known and idiopathic etiology, but no valid therapy is presently available. Previous evidence demonstrated that suberoylanilide hydroxamic acid (SAHA), a histone… read more here.
Keywords: fibrosis; apoptosis; epidural fibrosis; saha ... See more keywords
Mocetinostat suppresses epidural fibrosis following laminectomy by inhibiting myofibroblast activation and increasing apoptosis.
Sign Up to like & getrecommendations! Published in 2021 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202105_25801
Abstract: The article "Mocetinostat suppresses epidural fibrosis following laminectomy by inhibiting myofibroblast activation and increasing apoptosis, by W.-J. Wu, J. Wang, J. Liang, Q. Zhou, Y. Liang, published in Eur Rev Med Pharmacol Sci 2020; 24… read more here.
Keywords: mocetinostat suppresses; epidural fibrosis; following laminectomy; laminectomy inhibiting ... See more keywords
The Preventive Effect of Decorin on Epidural Fibrosis and Epidural Adhesions After Laminectomy
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DOI: 10.3389/fphar.2021.774316
Abstract: Laminectomy is commonly performed to treat degenerative spinal diseases by reducing compression on the spinal cord and nerve roots. The postoperative epidural fibrosis and epidural adhesions may result in failed back surgery syndrome, which is… read more here.
Keywords: fibrosis epidural; epidural adhesions; epidural fibrosis; fibrosis ... See more keywords
Laminin α1 as a target for the treatment of epidural fibrosis by regulating fibrotic mechanisms
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DOI: 10.3892/ijmm.2022.5205
Abstract: Excessive proliferation and migration of fibroblasts in the lumbar laminectomy area can lead to epidural fibrosis, eventually resulting in failed back surgery syndrome. It has been reported that laminin α1, a significant biofunctional glycoprotein in… read more here.
Keywords: apoptosis; proliferation; laminin; migration ... See more keywords