Epigallocatechin‐3‐gallate sensitises multidrug‐resistant oral carcinoma xenografts to vincristine sulfate
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12905
Abstract: Oral squamous cell carcinoma (OSCC) is a very aggressive malignancy, and 50% of patients who receive curative treatment die from the disease or related complications within 5 years. Epigallocatechin‐3‐gallate (EGCG) is the most abundant bioactive… read more here.
Keywords: carcinoma; sensitises multidrug; epigallocatechin gallate; vincristine sulfate ... See more keywords
Epigallocatechin‐3‐Gallate Attenuates Benign Prostatic Hyperplasia Development via Regulating Firmicutes to Inhibit Gastric Secretion of Insulin‐Like Growth Factor‐1
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biology International"
DOI: 10.1002/cbin.70032
Abstract: Benign prostatic hyperplasia (BPH), a prevalent age‐related condition in men, is increasingly linked to metabolic syndrome (MetS) and gut microbiota dysbiosis. This study reveals how Firmicutes‐dominant microbial imbalance drives BPH progression via IGF‐1 signaling and… read more here.
Keywords: prostatic hyperplasia; bph; growth factor; benign prostatic ... See more keywords
(−)‐Epigallocatechin‐3‐gallate inhibits human angiotensin‐converting enzyme activity through an autoxidation‐dependent mechanism
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.21932
Abstract: We investigated the molecular mechanisms involved in the angiotensin‐converting enzyme (ACE) inhibition by (−)‐epigallocatechin‐3‐gallate (EGCg), a major tea catechin. EGCg inhibited both the ACE activity in the lysate of human colorectal cancer cells and human… read more here.
Keywords: converting enzyme; angiotensin converting; epigallocatechin gallate; ace ... See more keywords
Low dose epigallocatechin-3-gallate revives doxorubicin responsiveness by a redox-sensitive pathway in A549 lung adenocarcinoma cells.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.22999
Abstract: Pulmonary cancer confronts the greatest hurdle of resistance against most chemotherapeutic drugs. This may be circumvented with a combination of conventional chemotherapy with bioactive herbal adjuvant. Epigallocatechin-3-gallate (EGCG), was investigated for its chemo-sensitizing property along… read more here.
Keywords: low dose; a549; epigallocatechin gallate; lung adenocarcinoma ... See more keywords
Theaflavin and epigallocatechin‐3‐gallate synergistically induce apoptosis through inhibition of PI3K/Akt signaling upon depolymerizing microtubules in HeLa cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27886
Abstract: Theaflavin (TF) and epigallocatechin‐3‐gallate (EGCG) both have been reported previously as microtubule depolymerizing agents that also have anticancer effects on various cancer cell lines and in animal models. Here, we have applied TF and EGCG… read more here.
Keywords: combination; akt signaling; theaflavin epigallocatechin; pi3k akt ... See more keywords
Exploring gastroprotective effect and mechanisms of epigallocatechin gallate‐impregnated black garlic in acidic ethanol‐induced gastric ulcer model mice
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the Science of Food and Agriculture"
DOI: 10.1002/jsfa.70109
Abstract: Peptic ulcers, particularly gastric ulcers (GUs), are multifactorial disorders with unclear mechanisms. Black garlic (BG) has shown gastroprotective effects. This study evaluated the effects of BG and epigallocatechin gallate‐impregnated BG (EG) in acidic ethanol (AE)‐induced… read more here.
Keywords: ethanol induced; model mice; acidic ethanol; gallate impregnated ... See more keywords
(‐)‐Epigallocatechin‐3‐Gallate Antihyperalgesic Effect Associates With Reduced CX3CL1 Chemokine Expression in Spinal Cord
Sign Up to like & getrecommendations! Published in 2017 at "Phytotherapy Research"
DOI: 10.1002/ptr.5753
Abstract: (‐)‐Epigallocatechin‐3‐gallate (EGCG) is a major polyphenol in green tea with beneficial effects on the neuropathic pain alleviation in animal models. Because chemokine fractalkine (CX3CL1) has been suggested as an important signal during neuropathic pain development,… read more here.
Keywords: antihyperalgesic effect; egcg treatment; epigallocatechin gallate; expression ... See more keywords
(-)-Epigallocatechin-3-gallate provides neuroprotection via AMPK activation against traumatic brain injury in a mouse model
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-020-01841-1
Abstract: Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. (-)-Epigallocatechin-3-gallate (EGCG) has shown robust neuroprotective effects on various brain injury models in rodents. Herein, we aimed to investigate if EGCG protects… read more here.
Keywords: epigallocatechin gallate; brain injury; injury; traumatic brain ... See more keywords
Identification of potential human targets for epigallocatechin gallate through a novel protein binding site screening approach
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-025-06410-y
Abstract: Epigallocatechin-3-gallate (EGCG), a compound found in green tea, is known for its anticancer properties, although its specific protein targets remain largely undefined. In this study, we identified EGCG targets across the human proteome using a… read more here.
Keywords: binding site; site screening; novel protein; protein ... See more keywords
Epigallocatechin gallate protects against homocysteine-induced vascular smooth muscle cell proliferation
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-3142-6
Abstract: Epigallocatechin gallate (EGCG), a bioactive ingredient of green tea, plays a protective role in the cardiovascular system. Homocysteine (Hcy) is a major risk factor for chronic kidney disease and cardiovascular disease. The present study aimed… read more here.
Keywords: vascular smooth; epigallocatechin gallate; proliferation; expression ... See more keywords
Epigallocatechin 3-gallate-induced neuroprotection in neurodegenerative diseases: molecular mechanisms and clinical insights
Sign Up to like & getrecommendations! Published in 2025 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-025-05211-4
Abstract: Neurodegenerative diseases (NDs) are caused by progressive neuronal death and cognitive decline. Epigallocatechin 3-gallate (EGCG) is a polyphenolic molecule in green tea as a neuroprotective agent. This review evaluates the therapeutic effects of EGCG and… read more here.
Keywords: oxidative stress; molecular mechanisms; cell; neurodegenerative diseases ... See more keywords