Analysis of Epigenetic Age Acceleration and Healthy Longevity Among Older US Women
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.23285
Abstract: This cohort study investigates the association of epigenetic age acceleration with odds of surviving to age 90 with intact function among older US women. read more here.
Keywords: among older; epigenetic age; older women; age ... See more keywords
Accelerated extrinsic epigenetic aging and increased natural killer cells in blood of suicide completers
Sign Up to like & getrecommendations! Published in 2020 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2019.109805
Abstract: BACKGROUND Studies suggest aberrant DNA methylation in victims of suicide. Recently, DNA methylation profiles have been developed for determining "epigenetic age," which is the most accurate estimate of biological age. Subsequently, two refined measures of… read more here.
Keywords: suicide completers; epigenetic aging; blood; extrinsic epigenetic ... See more keywords
Gene expression correlates of advanced epigenetic age and psychopathology in postmortem cortical tissue
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Stress"
DOI: 10.1016/j.ynstr.2021.100371
Abstract: Psychiatric stress has been associated with accelerated epigenetic aging (i.e., when estimates of cellular age based on DNA methylation exceed chronological age) in both blood and brain tissue. Little is known about the downstream biological… read more here.
Keywords: epigenetic age; age; psychopathology; gene expression ... See more keywords
The acute effects of adjuvant radiation and chemotherapy on peripheral blood epigenetic age in early stage breast cancer patients
Sign Up to like & getrecommendations! Published in 2020 at "NPJ Breast Cancer"
DOI: 10.1038/s41523-020-0161-3
Abstract: Survival has increased in early stage breast cancer (BC), and the late effects of treatment persist for decades. Molecular mechanisms underlying the acceleration of age-related diseases after chemotherapy and radiotherapy are poorly understood. We examined… read more here.
Keywords: age; breast cancer; epigenetic age; early stage ... See more keywords
Epigenetic age reversal by cell-extrinsic and cell-intrinsic means.
Sign Up to like & getrecommendations! Published in 2019 at "Rejuvenation research"
DOI: 10.1089/rej.2019.2271
Abstract: Reversal of aging by factors or drugs that reprogram adult cells to induce pluripotent stem cells (iPSC) suggests that at least at the cellular level aging may be reversible by resetting somatic cell state to… read more here.
Keywords: dnama; reversal; cell extrinsic; age ... See more keywords
The effects of epigenetic age and its acceleration on surface area, cortical thickness, and volume in young adults.
Sign Up to like & getrecommendations! Published in 2022 at "Cerebral cortex"
DOI: 10.1093/cercor/bhac043
Abstract: DNA methylation age has been used in recent studies as an epigenetic marker of accelerated cellular aging, whose contribution to the brain structural changes was lately acknowledged. We aimed to characterize the association of epigenetic… read more here.
Keywords: cortical thickness; epigenetic age; volume; age ... See more keywords
Epigenetic Age Acceleration and Chronic Health Conditions among Adult Survivors of Childhood Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the National Cancer Institute"
DOI: 10.1093/jnci/djaa147
Abstract: BACKGROUND Mounting evidence supports the occurrence of accelerating aging among long-term survivors of childhood cancer. We aimed to investigate epigenetic age acceleration (EAA) in survivors and evaluate associations between EAA, treatment exposures, health behaviors, and… read more here.
Keywords: survivors childhood; cancer; health; epigenetic age ... See more keywords
Models of epigenetic age capture patterns of DNA methylation in glioma associated with molecular subtype, survival, and recurrence
Sign Up to like & getrecommendations! Published in 2018 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noy003
Abstract: Background Models of epigenetic aging (epigenetic clocks) have been implicated as potentially useful markers for cancer risk and prognosis. Using 2 previously published methods for modeling epigenetic age, Horvath's clock and epiTOC, we investigated epigenetic… read more here.
Keywords: epigenetic aging; recurrence; glioma; age ... See more keywords
The association between adverse childhood experiences and epigenetic age acceleration in the Canadian longitudinal study on aging (CLSA)
Sign Up to like & getrecommendations! Published in 2023 at "Aging Cell"
DOI: 10.1111/acel.13779
Abstract: Research examining the association between exposure to a wide range of adverse childhood experiences (ACEs) and accelerated biological aging in older adults is limited. The purpose of this study was to examine the association of… read more here.
Keywords: acceleration; epigenetic age; age acceleration; association ... See more keywords
Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abq2226
Abstract: Aging is associated with an increased risk of frailty, disability, and mortality. Strategies to delay the degenerative changes associated with aging and frailty are particularly interesting. We treated old animals with small extracellular vesicles (sEVs)… read more here.
Keywords: extracellular vesicles; epigenetic age; old mice; small extracellular ... See more keywords
Abstract 5414: Epigenetic age acceleration and chronic health conditions among adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-5414
Abstract: Background: The epigenetic clock becomes an important biomarker in aging research, where epigenetic age (EA) approximates chronological age with high accuracy and epigenetic age acceleration (EAA) demonstrates superior performance in predicting health outcomes in the… read more here.
Keywords: survivors childhood; age; cancer; health ... See more keywords