Childhood Maltreatment and Longitudinal Epigenetic Aging
Sign Up to like & getrecommendations! Published in 2024 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2024.21877
Abstract: Key Points Question Are longitudinal, developmental influences of child maltreatment during early childhood and midchildhood associated with epigenetic signatures of accelerated aging in later childhood and adolescence? Findings In a cohort study of 1971 children… read more here.
Keywords: age; childhood; epigenetic aging; maltreatment longitudinal ... See more keywords
Epigenetic aging in older breast cancer survivors and non-cancer controls: preliminary findings from the Thinking and Living with Cancer (TLC) Study.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34818
Abstract: BACKGROUND Cancer and its treatments may accelerate aging in survivors; however, research has not examined epigenetic markers of aging in longer term breast cancer survivors. This study examined whether older breast cancer survivors showed greater… read more here.
Keywords: older breast; epigenetic aging; breast cancer; cancer ... See more keywords
Epigenetic aging in adult neurogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Hippocampus"
DOI: 10.1002/hipo.23494
Abstract: Neural stem cells (NSCs) in the hippocampus generate new neurons throughout life, which functionally contribute to cognitive flexibility and mood regulation. Yet adult hippocampal neurogenesis substantially declines with age and age‐related impairments in NSC activity… read more here.
Keywords: aging adult; adult neurogenesis; epigenetic aging; neurogenesis ... See more keywords
The role of protective genetic variants in modulating epigenetic aging
Sign Up to like & getrecommendations! Published in 2025 at "GeroScience"
DOI: 10.1007/s11357-025-01548-2
Abstract: Several progeroid syndromes’ causative mutations have been linked to epigenetic age acceleration as measured via several epigenetic clocks. At the same time, several protective variants have also been discovered that can reduce the risk of… read more here.
Keywords: age; role protective; epigenetic aging; protective variants ... See more keywords
Associations of epigenetic aging and COVID- 19: A 3-year longitudinal study
Sign Up to like & getrecommendations! Published in 2025 at "GeroScience"
DOI: 10.1007/s11357-025-01635-4
Abstract: Aging and COVID- 19 are known to influence DNA methylation, potentially affecting the rate of aging and the risk of disease. The physiological functions of 54 volunteers—including maximal oxygen uptake (VO₂ max), grip strength, and… read more here.
Keywords: year; associations epigenetic; aging covid; covid year ... See more keywords
Accelerated extrinsic epigenetic aging and increased natural killer cells in blood of suicide completers
Sign Up to like & getrecommendations! Published in 2020 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2019.109805
Abstract: BACKGROUND Studies suggest aberrant DNA methylation in victims of suicide. Recently, DNA methylation profiles have been developed for determining "epigenetic age," which is the most accurate estimate of biological age. Subsequently, two refined measures of… read more here.
Keywords: suicide completers; epigenetic aging; blood; extrinsic epigenetic ... See more keywords
Accelerated epigenetic aging mediates link between adverse childhood experiences and depressive symptoms in older adults: Results from the Health and Retirement Study
Sign Up to like & getrecommendations! Published in 2022 at "SSM - Population Health"
DOI: 10.1016/j.ssmph.2022.101071
Abstract: Adverse childhood experiences (ACEs) increase risk for depression at subsequent ages and have been linked to accelerated biological aging. We hypothesize that accelerated epigenetic aging may partially mediate the link between ACEs and depression. This… read more here.
Keywords: symptoms older; study; epigenetic aging; health ... See more keywords
Epigenetic aging and PTSD outcomes in the immediate aftermath of trauma.
Sign Up to like & getrecommendations! Published in 2023 at "Psychological medicine"
DOI: 10.1017/s0033291723000636
Abstract: BACKGROUND Psychological trauma exposure and posttraumatic stress disorder (PTSD) have been associated with advanced epigenetic age. However, whether epigenetic aging measured at the time of trauma predicts the subsequent development of PTSD outcomes is unknown.… read more here.
Keywords: ptsd outcomes; aging ptsd; trauma; epigenetic aging ... See more keywords
Lagged effects of childhood depressive symptoms on adult epigenetic aging
Sign Up to like & getrecommendations! Published in 2024 at "Psychological Medicine"
DOI: 10.1017/s0033291724001570
Abstract: Background Cross-sectional studies have identified health risks associated with epigenetic aging. However, it is unclear whether these risks make epigenetic clocks ‘tick faster’ (i.e. accelerate biological aging). The current study examines concurrent and lagged within-person… read more here.
Keywords: lagged effects; health risks; epigenetic aging; depressive symptoms ... See more keywords
Accelerated epigenetic aging at birth interacts with parenting hostility to predict child temperament and subsequent psychological symptoms.
Sign Up to like & getrecommendations! Published in 2021 at "Development and psychopathology"
DOI: 10.1017/s0954579421000614
Abstract: In an effort to elucidate new factors that may contribute to developmental psychopathology, the current study examined whether accelerated epigenetic aging at birth related to children's differential susceptibility to the effects of aversive parenting on… read more here.
Keywords: psychological symptoms; epigenetic aging; aging birth; psychopathology ... See more keywords
Adolescent peer struggles predict accelerated epigenetic aging in midlife.
Sign Up to like & getrecommendations! Published in 2022 at "Development and psychopathology"
DOI: 10.1017/s0954579422000153
Abstract: This study examined struggles to establish autonomy and relatedness with peers in adolescence and early adulthood as predictors of advanced epigenetic aging assessed at age 30. Participants (N = 154; 67 male and 87 female)… read more here.
Keywords: predict accelerated; age; epigenetic aging; peer struggles ... See more keywords