Epigenetic aging in older breast cancer survivors and non-cancer controls: preliminary findings from the Thinking and Living with Cancer (TLC) Study.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34818
Abstract: BACKGROUND Cancer and its treatments may accelerate aging in survivors; however, research has not examined epigenetic markers of aging in longer term breast cancer survivors. This study examined whether older breast cancer survivors showed greater… read more here.
Keywords: older breast; epigenetic aging; breast cancer; cancer ... See more keywords
Epigenetic aging in adult neurogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Hippocampus"
DOI: 10.1002/hipo.23494
Abstract: Neural stem cells (NSCs) in the hippocampus generate new neurons throughout life, which functionally contribute to cognitive flexibility and mood regulation. Yet adult hippocampal neurogenesis substantially declines with age and age‐related impairments in NSC activity… read more here.
Keywords: aging adult; adult neurogenesis; epigenetic aging; neurogenesis ... See more keywords
Accelerated extrinsic epigenetic aging and increased natural killer cells in blood of suicide completers
Sign Up to like & getrecommendations! Published in 2020 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2019.109805
Abstract: BACKGROUND Studies suggest aberrant DNA methylation in victims of suicide. Recently, DNA methylation profiles have been developed for determining "epigenetic age," which is the most accurate estimate of biological age. Subsequently, two refined measures of… read more here.
Keywords: suicide completers; epigenetic aging; blood; extrinsic epigenetic ... See more keywords
Accelerated epigenetic aging mediates link between adverse childhood experiences and depressive symptoms in older adults: Results from the Health and Retirement Study
Sign Up to like & getrecommendations! Published in 2022 at "SSM - Population Health"
DOI: 10.1016/j.ssmph.2022.101071
Abstract: Adverse childhood experiences (ACEs) increase risk for depression at subsequent ages and have been linked to accelerated biological aging. We hypothesize that accelerated epigenetic aging may partially mediate the link between ACEs and depression. This… read more here.
Keywords: symptoms older; study; epigenetic aging; health ... See more keywords
Epigenetic aging and PTSD outcomes in the immediate aftermath of trauma.
Sign Up to like & getrecommendations! Published in 2023 at "Psychological medicine"
DOI: 10.1017/s0033291723000636
Abstract: BACKGROUND Psychological trauma exposure and posttraumatic stress disorder (PTSD) have been associated with advanced epigenetic age. However, whether epigenetic aging measured at the time of trauma predicts the subsequent development of PTSD outcomes is unknown.… read more here.
Keywords: ptsd outcomes; aging ptsd; trauma; epigenetic aging ... See more keywords
Accelerated epigenetic aging at birth interacts with parenting hostility to predict child temperament and subsequent psychological symptoms.
Sign Up to like & getrecommendations! Published in 2021 at "Development and psychopathology"
DOI: 10.1017/s0954579421000614
Abstract: In an effort to elucidate new factors that may contribute to developmental psychopathology, the current study examined whether accelerated epigenetic aging at birth related to children's differential susceptibility to the effects of aversive parenting on… read more here.
Keywords: psychological symptoms; epigenetic aging; aging birth; psychopathology ... See more keywords
Adolescent peer struggles predict accelerated epigenetic aging in midlife.
Sign Up to like & getrecommendations! Published in 2022 at "Development and psychopathology"
DOI: 10.1017/s0954579422000153
Abstract: This study examined struggles to establish autonomy and relatedness with peers in adolescence and early adulthood as predictors of advanced epigenetic aging assessed at age 30. Participants (N = 154; 67 male and 87 female)… read more here.
Keywords: predict accelerated; age; epigenetic aging; peer struggles ... See more keywords
GWAS of epigenetic aging rates in blood reveals a critical role for TERT
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-02697-5
Abstract: DNA methylation age is an accurate biomarker of chronological age and predicts lifespan, but its underlying molecular mechanisms are unknown. In this genome-wide association study of 9907 individuals, we find gene variants mapping to five… read more here.
Keywords: epigenetic aging; age; critical role; gwas epigenetic ... See more keywords
In utero exposure to the Great Depression is reflected in late-life epigenetic aging signatures
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208530119
Abstract: Research on maternal-fetal epigenetic programming argues that adverse exposures to the intrauterine environment can have long-term effects on adult morbidity and mortality. However, causal research on epigenetic programming in humans at a population level is… read more here.
Keywords: great depression; late life; epigenetic aging; life ... See more keywords
Models of epigenetic age capture patterns of DNA methylation in glioma associated with molecular subtype, survival, and recurrence
Sign Up to like & getrecommendations! Published in 2018 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noy003
Abstract: Background Models of epigenetic aging (epigenetic clocks) have been implicated as potentially useful markers for cancer risk and prognosis. Using 2 previously published methods for modeling epigenetic age, Horvath's clock and epiTOC, we investigated epigenetic… read more here.
Keywords: epigenetic aging; recurrence; glioma; age ... See more keywords
Accelerated epigenetic aging in newborns with Down syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13652
Abstract: Accelerated aging is a hallmark of Down syndrome (DS), with adults experiencing early‐onset Alzheimer's disease and premature aging of the skin, hair, and immune and endocrine systems. Accelerated epigenetic aging has been found in the… read more here.
Keywords: accelerated epigenetic; age; epigenetic aging; age acceleration ... See more keywords