Epigenetic alterations in glioblastomas: Diagnostic, prognostic and therapeutic relevance.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of cancer"
DOI: 10.1002/ijc.34381
Abstract: Glioblastoma, the most common and heterogeneous tumor affecting brain parenchyma, is dismally characterized by a very poor prognosis. Thus, the search of new, more effective treatments is a vital need. Here, we will review the… read more here.
Keywords: epigenetic alterations; alterations glioblastomas; prognostic therapeutic; therapeutic relevance ... See more keywords
The critical role of epigenetic mechanisms involved in nanotoxicology.
Sign Up to like & getrecommendations! Published in 2022 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1789
Abstract: Over the past decades, nanomaterials (NMs) have been widely applied in the cosmetic, food, engineering, and medical fields. Along with the prevalence of NMs, the toxicological characteristics exhibited by these materials on health and the… read more here.
Keywords: epigenetic alterations; methylation; role; role epigenetic ... See more keywords
Genetic and epigenetic alterations in meningiomas
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2017.05.002
Abstract: Meningiomas originate from the arachnoid layer of the meninges and divided histologically into three grades: benign (grade I), atypical (grade II), and malignant meningiomas (grade III). Genetic alterations in grade I meningiomas include frequent deletions… read more here.
Keywords: grade meningiomas; alterations meningiomas; meningiomas; genetic epigenetic ... See more keywords
Epigenetics in renal cell cancer: mechanisms and clinical applications
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Urology"
DOI: 10.1038/s41585-018-0023-z
Abstract: Renal cell carcinoma (RCC) is characterized by an infrequent number of somatic mutations. By contrast, epigenetic aberrations are commonly found in RCC, indicating that epigenetic reprogramming is an important event in RCC development. Epigenetic alterations… read more here.
Keywords: renal cell; rcc; signalling pathways; cancer ... See more keywords
Epigenetic alterations in stem cell ageing-a promising target for age-reversing interventions?
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in functional genomics"
DOI: 10.1093/bfgp/elab010
Abstract: Ageing is accompanied by loss of tissue integrity and organismal homeostasis partly due to decline in stem cell function. The age-associated decrease in stem cell abundance and activity is often referred to as stem cell… read more here.
Keywords: age; interventions epigenetic; stem cell; cell ... See more keywords
Epigenetic alterations of testicular germ cell tumours.
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Urology"
DOI: 10.1097/mou.0000000000000724
Abstract: PURPOSE OF REVIEW Testicular germ cell tumours (TGCTs) exhibit, in contrast to other cancer types, a relatively low mutational burden. However, numerous epigenetic alterations have been shown to impact TGCT. In this review, we summarize… read more here.
Keywords: germ cell; testicular germ; epigenetic alterations; cell tumours ... See more keywords
Epigenetic alterations in salivary gland tumors.
Sign Up to like & getrecommendations! Published in 2019 at "Oral diseases"
DOI: 10.1111/odi.13253
Abstract: Salivary gland tumors (SGT) comprise a heterogeneous group of benign and malignant neoplasms that exhibit significant variability in their microscopic appearance, clinical presentation and biological behavior. The etiologic factors are unknown, however, chromosomic translocation, secondary… read more here.
Keywords: gland tumors; alterations salivary; salivary gland; development ... See more keywords
Shared epigenetic alterations between oral cancer and periodontitis: a preliminary study.
Sign Up to like & getrecommendations! Published in 2022 at "Oral diseases"
DOI: 10.1111/odi.14251
Abstract: INTRODUCTION We recently developed a non-invasive sampling procedure for oral squamous cell carcinoma (OSCC) detection based on DNA methylation analysis of a panel of 13 genes. Oral cancer, as well as acute and chronic inflammatory… read more here.
Keywords: methylation; oral cancer; shared epigenetic; oscc patients ... See more keywords
DNA Oncogenic Virus-Induced Oxidative Stress, Genomic Damage, and Aberrant Epigenetic Alterations
Sign Up to like & getrecommendations! Published in 2017 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2017/3179421
Abstract: Approximately 20% of human cancers is attributable to DNA oncogenic viruses such as human papillomavirus (HPV), hepatitis B virus (HBV), and Epstein-Barr virus (EBV). Unrepaired DNA damage is the most common and overlapping feature of… read more here.
Keywords: dna oncogenic; virus induced; damage; virus ... See more keywords
Epigenetic Alterations under Oxidative Stress in Stem Cells
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/6439097
Abstract: Epigenetic regulation of gene expression, including DNA methylation and histone modifications, provides finely tuned responses for cells that undergo cellular environment changes. Abundant evidences have demonstrated the detrimental role of oxidative stress in various human… read more here.
Keywords: stress; oxidative stress; alterations oxidative; stem cells ... See more keywords
Epigenetic Alterations and Mechanisms That Drive Resistance to Targeted Cancer Therapies
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Research"
DOI: 10.1158/0008-5472.can-21-1606
Abstract: Cancer is a complex disease and cancer cells typically harbor multiple genetic and epigenetic alterations. Large-scale sequencing of patient-derived cancer samples has identified several druggable driver oncogenes. Many of these oncogenes can be pharmacologically targeted… read more here.
Keywords: cancer types; resistance targeted; cancer; resistance ... See more keywords