Integrated genetic and epigenetic analysis revealed heterogeneity of acute lymphoblastic leukemia in Down syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Science"
DOI: 10.1111/cas.14160
Abstract: Children with Down syndrome (DS) are at a 20‐fold increased risk for acute lymphoblastic leukemia (ALL). Compared to children with ALL and no DS (non‐DS‐ALL), those with DS and ALL (DS‐ALL) harbor uncommon genetic alterations,… read more here.
Keywords: epigenetic analysis; lymphoblastic leukemia; integrated genetic; acute lymphoblastic ... See more keywords
Genetic and epigenetic analysis of hepatocellular adenomas with atypical morphological features
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DOI: 10.1111/his.14858
Abstract: Hepatocellular adenoma (HCA) is a rare liver tumour, which can have atypical morphological features such as cytological atypia, pseudoglandular architecture, and altered reticulin framework. Little is known about the genetic and epigenetic alterations of such… read more here.
Keywords: analysis hepatocellular; epigenetic analysis; atypical morphological; morphological features ... See more keywords
Epigenetic analysis reveals significant differential expression of miR‐378C and miR‐128‐2‐5p in a cohort of relapsed pediatric B‐acute lymphoblastic leukemia cases
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Laboratory Hematology"
DOI: 10.1111/ijlh.13477
Abstract: Epigenetic changes play a major role in mediating chemoresistance and relapse in pediatric ALL, and hence in current pilot study, we tried to identify DNA methylation, miRNA expression, and copy number variations (CNVs) in a… read more here.
Keywords: analysis reveals; reveals significant; significant differential; cohort ... See more keywords
Clinical Application of Sequential Epigenetic Analysis for Diagnosis of Silver–Russell Syndrome
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DOI: 10.3343/alm.2021.41.4.401
Abstract: Background Silver-Russell syndrome (SRS) is a pre- or post-natal growth retardation disorder caused by (epi)genetic alterations. We evaluated the molecular basis and clinical value of sequential epigenetic analysis in pediatric patients with SRS. Methods Twenty-eight… read more here.
Keywords: methylation; russell syndrome; silver russell; analysis ... See more keywords
Precise Epigenetic Analysis Using Targeted Bisulfite Genomic Sequencing Distinguishes FSHD1, FSHD2, and Healthy Subjects
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DOI: 10.3390/diagnostics11081469
Abstract: The true prevalence of facioscapulohumeral muscular dystrophy (FSHD) is unknown due to difficulties with accurate clinical evaluation and the complexities of current genetic diagnostics. Interestingly, all forms of FSHD are linked to epigenetic changes in… read more here.
Keywords: genomic sequencing; fshd; fshd1 fshd2; bisulfite genomic ... See more keywords
Modeling DNA Methylation Profiles and Epigenetic Analysis of Safflower (Carthamus tinctorius L.) Seedlings Exposed to Copper Heavy Metal
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DOI: 10.3390/toxics11030255
Abstract: Heavy metals are chemical elements with high density that can be toxic or poisonous even at low concentrations. They are widely distributed in the environment due to industrial activities, mining, pesticide use, automotive emissions and… read more here.
Keywords: methylation; heavy metal; copper heavy; epigenetic analysis ... See more keywords