Emerging Epigenetic‐Based Nanotechnology for Cancer Therapy: Modulating the Tumor Microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202206169
Abstract: Dysregulated epigenetic modifications dynamically drive the abnormal transcription process to affect the tumor microenvironment; thus, promoting cancer progression, drug resistance, and metastasis. Nowadays, therapies targeting epigenetic dysregulation of tumor cells and immune cells in the… read more here.
Keywords: epigenetic based; cancer; nanotechnology; tumor microenvironment ... See more keywords
Epigenetic‐based therapy for colorectal cancer: Prospect and involved mechanisms
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28658
Abstract: Epigenetic modifications are heritable variations in gene expression not encoded by the DNA sequence. According to reports, a large number of studies have been performed to characterize epigenetic modification during normal development and also in… read more here.
Keywords: colorectal cancer; crc; cancer; based therapy ... See more keywords
Epigenetic-based cancer therapeutics: new potential HDAC8 inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1813203
Abstract: Abstract Designing dual small molecule inhibitors against enzymes associated with cancer has turned into a new strategy in cancer chemotherapy. Targeting DNA methyltransferase (DNMT) and histone deacetylase (HDAC) enzymes, involved in epigenetic modifications, are considered… read more here.
Keywords: cancer; therapeutics new; cancer therapeutics; hdac8 ... See more keywords
Epigenetic based synthetic lethal strategies in human cancers
Sign Up to like & getrecommendations! Published in 2020 at "Biomarker Research"
DOI: 10.1186/s40364-020-00224-1
Abstract: Over the past decades, it is recognized that loss of DNA damage repair (DDR) pathways is an early and frequent event in tumorigenesis, occurring in 40-50% of many cancer types. The basis of synthetic lethality… read more here.
Keywords: based synthetic; human cancers; synthetic lethality; cancer ... See more keywords
m6A RNA Methylation in Systemic Autoimmune Diseases—A New Target for Epigenetic-Based Therapy?
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceuticals"
DOI: 10.3390/ph14030218
Abstract: The general background of autoimmune diseases is a combination of genetic, epigenetic and environmental factors, that lead to defective immune reactions. This erroneous immune cell activation results in an excessive production of autoantibodies and prolonged… read more here.
Keywords: autoimmune; target epigenetic; autoimmune diseases; m6a ... See more keywords