Epigenetic Clock Acceleration Is Linked to Age at Onset of Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.29157
Abstract: Aging is the strongest risk factor for Parkinson's disease (PD), which is a clinically heterogeneous movement disorder with highly variable age at onset. DNA methylation age (DNAm age) is an epigenetic clock that could reflect… read more here.
Keywords: age onset; parkinson disease; epigenetic clock; age ... See more keywords
A HIERARCHICAL MODEL FOR THE CONTROL OF EPIGENETIC AGING IN MAMMALS
Sign Up to like & getrecommendations! Published in 2020 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2020.101134
Abstract: Regulatory mechanisms range from a single level of control in simple metazoans to multi-level hierarchical control networks in higher animals. Organismal regulation encompasses homeostatic and circadian networks that are interconnected, with no documented exceptions. The… read more here.
Keywords: control; model control; hierarchical model; clock ... See more keywords
233. Indices of Cellular Health are Associated With Antidepressant Treatment Response
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2018.02.252
Abstract: Background: Advances in the study of biological aging have identified that DNAmethylation data can be used to index cellular age and to evaluate pathogenic factors that accelerate aging. Stress, trauma, and posttraumatic stress disorder (PTSD)… read more here.
Keywords: pace epigenetic; age; epigenetic clock; psychopathology ... See more keywords
Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging
Sign Up to like & getrecommendations! Published in 2021 at "Aging Cell"
DOI: 10.1111/acel.13349
Abstract: Cattle are an attractive animal model of fertility in women due to their high degree of similarity relative to follicle selection, embryo cleavage, blastocyst formation, and gestation length. To facilitate future studies of the epigenetic… read more here.
Keywords: methylation; aging epigenetic; model; reproductive aging ... See more keywords