Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume.
Sign Up to like & getrecommendations! Published in 2022 at "GeroScience"
DOI: 10.1007/s11357-022-00558-8
Abstract: The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to age-related disorders, such as Alzheimer's Disease (AD). Whilst studies have reported associations with AD… read more here.
Keywords: hippocampal volume; age acceleration; age; epigenetic clocks ... See more keywords
The association of epigenetic clocks in brain tissue with brain pathologies and common aging phenotypes
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2021.105428
Abstract: Epigenetic clocks are calculated by combining DNA methylation states across select CpG sites to estimate biologic age, and have been noted as the most successful markers of biologic aging to date. Yet, limited research has… read more here.
Keywords: age; tissue; pathology; epigenetic clocks ... See more keywords
DNA methylation based biomarkers for aging long-lived cetaceans.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular ecology resources"
DOI: 10.1111/1755-0998.13791
Abstract: Epigenetic approaches for estimating the age of living organisms are revolutionizing studies of long-lived species. Molecular biomarkers that allow age estimates from small tissue biopsies promise to enhance studies of long-lived whales; addressing a fundamental… read more here.
Keywords: epigenetic clocks; long lived; dna methylation; age ... See more keywords
Epigenetic clocks, aging, and cancer
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DOI: 10.1126/science.abn4009
Abstract: Description Global methylation changes in aging cells affect cancer risk and tissue homeostasis Cancer and aging are accompanied by stereotyped changes to the epigenetic landscape, including progressive loss of DNA methylation over gene-poor genomic regions… read more here.
Keywords: aging cancer; methylation; cancer; epigenetic clocks ... See more keywords
The influences of DNA methylation and epigenetic clocks, on metabolic disease, in middle-aged Koreans
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Epigenetics"
DOI: 10.1186/s13148-020-00936-z
Abstract: Background Considering that DNA methylation (DNAm) profiles are, in large part, modifiable by lifestyle and environmental influences, it has been proposed that epigenetic clocks provide a better estimate of biological age than chronological age, as… read more here.
Keywords: methylation; age; grimage; age group ... See more keywords
Epigenetic clocks and female fertility timeline: A new approach to an old issue?
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1121231
Abstract: Worldwide increase in life expectancy has boosted research on aging. Overcoming the concept of chronological age, higher attention has been addressed to biological age, which reflects a person’s real health state, and which may be… read more here.
Keywords: fertility timeline; epigenetic clocks; age; fertility ... See more keywords
Assessing the Causal Association between Biological Aging Biomarkers and the Development of Cerebral Small Vessel Disease: A Mendelian Randomization Study
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DOI: 10.3390/biology12050660
Abstract: Simple Summary Chronological aging has long been considered an immutable risk factor for cerebral small vessel disease, but recent studies have revealed the potential for biological aging to be modulated and possibly even slowed or… read more here.
Keywords: epigenetic clocks; vessel disease; disease; cerebral small ... See more keywords
Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study.
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.75374
Abstract: Background: Epigenetic clocks have been associated with cancer risk in several observational studies. Nevertheless, it is unclear whether they play a causal role in cancer risk or if they act as a non-causal biomarker. Methods:… read more here.
Keywords: cancer; study; acceleration; research ... See more keywords